Preparation, characterization and antimalarial activity of dihydroartemisinin / β-cyclodextrin spray-dried powder
Issued Date
2022-07-01
Resource Type
ISSN
17732247
Scopus ID
2-s2.0-85130785777
Journal Title
Journal of Drug Delivery Science and Technology
Volume
73
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Drug Delivery Science and Technology Vol.73 (2022)
Suggested Citation
Pongsamart K., Limwikrant W., Ruktanonchai U.R., Charoenthai N., Puttipipatkhachorn S. Preparation, characterization and antimalarial activity of dihydroartemisinin / β-cyclodextrin spray-dried powder. Journal of Drug Delivery Science and Technology Vol.73 (2022). doi:10.1016/j.jddst.2022.103434 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86851
Title
Preparation, characterization and antimalarial activity of dihydroartemisinin / β-cyclodextrin spray-dried powder
Author's Affiliation
Other Contributor(s)
Abstract
In this study a factorial design was used to optimize process conditions to produce spray-dried powder of dihydroartemisinin (DHA) with β-cyclodextrin (β-CD). Predicted conditions for maximum yield and minimum residual moisture were as follows: inlet temperature; 120 °C, aspirator setting; 100%, feed rate; 25%, and molar ratio of DHA:β-CD; 1:2. The higher percent inclusion yield was obtained in the spray-dried powder with lower molar ratio of DHA:β-CD. DHA existed in amorphous state in the spray-dried powder with 1:2 M ratio of DHA:β-CD whereas it was in crystalline state in the spray-dried powder with 2:1 M ratio of DHA:β-CD. The inclusion complex formation between DHA and β-CD was revealed by FTIR study. The spray-dried powder of DHA with β-CD showed dramatically enhanced dissolution rate with unchanged antimalarial activity. Moreover, it was chemically and physically stable at 30 °C, 75%RH for 3 months after storage.