A nonadride derivative from the marine-derived fungus Aspergillus chevalieri PSU-AMF79
Issued Date
2022-01-01
Resource Type
ISSN
14786419
eISSN
14786427
Scopus ID
2-s2.0-85124719887
Pubmed ID
35168452
Journal Title
Natural Product Research
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research (2022)
Suggested Citation
Ningsih B.N.S., Rukachaisirikul V., Phongpaichit S., Preedanon S., Sakayaroj J., Muanprasat C. A nonadride derivative from the marine-derived fungus Aspergillus chevalieri PSU-AMF79. Natural Product Research (2022). doi:10.1080/14786419.2022.2039651 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83927
Title
A nonadride derivative from the marine-derived fungus Aspergillus chevalieri PSU-AMF79
Other Contributor(s)
Abstract
One new nonadride enantiomer, ent-epiheveadride, along with five known dioxopiperazine derivatives were isolated from the marine-derived fungus Aspergillus chevalieri PSU-AMF79. Their structures were identified by extensive spectroscopic analysis. The absolute configuration of ent-epiheveadride was determined by comparison of the specific rotation and electronic circular dichroism data with those of related known compounds. It exhibited antifungal activity against Cryptococcus neoformans ATCC90113 flucytosine–resistant and Candida albicans NCPF3153 with the MIC values of 128 and 200 µg/mL, respectively. In addition, the known L-alanyl-L-tryptophan anhydride displayed TMEM16A inhibitory activity with 65.0% inhibition at a concentration of 5 µg/mL.