Vaccine-induced immune thrombotic thrombocytopenia with ChAdOx1 nCoV-19 is rare in Asia
Issued Date
2022-01-01
Resource Type
eISSN
24750379
Scopus ID
2-s2.0-85124487538
Journal Title
Research and Practice in Thrombosis and Haemostasis
Volume
6
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Research and Practice in Thrombosis and Haemostasis Vol.6 No.1 (2022)
Suggested Citation
Boonyawat K. Vaccine-induced immune thrombotic thrombocytopenia with ChAdOx1 nCoV-19 is rare in Asia. Research and Practice in Thrombosis and Haemostasis Vol.6 No.1 (2022). doi:10.1002/rth2.12644 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87433
Title
Vaccine-induced immune thrombotic thrombocytopenia with ChAdOx1 nCoV-19 is rare in Asia
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Background: Vaccination with ChAdOx1 n-CoV-19 is associated with a rare syndrome called vaccine-induced immune thrombotic thrombocytopenia (VITT). VITT has been reported mainly in Western countries, whereas the report of VITT in Asians is sparse. Objectives: To report a case series of VITT following ChAdOx1 n-CoV-19 in Thailand and to estimate the incidence of VITT among Asian countries. Methods: We retrieved the number of VITT patients and the total inoculation doses from the database of the Thai Ministry of Public Health. We performed a literature search including published articles and gray literature to estimate the incidence of VITT. The incidences of VITT by countries and respective confidence intervals were calculated. Results: By the end of August 2021, five VITT cases occurred after 15 million doses of ChAdOx1 n-CoV-19 in Thailand. The median age was 31 years, and 60% were women. The incidence of VITT is estimated at 1 in 3 million. In other Asian countries, only a few cases of VITT have been reported. The incidence of VITT is much lower than in those of Western countries, which is estimated at 1 in 100, 000. The fatality rate was 44% in this study. Conclusions: Although the incidence of VITT in Asians is low, the mortality rate is substantially higher. We urge that public awareness of this syndrome be raised, as early recognition and appropriate treatment of this syndrome following ChAdOx1 n-CoV-19 are crucial to improve the outcome.