In Silico Study of Functional Network Analysis Focusing on Antipsychotic Drugs and Cognitive Function in Schizophrenia
Issued Date
2025-12-02
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-105023901272
Journal Title
Siriraj Medical Journal
Volume
77
Issue
12
Start Page
847
End Page
857
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.77 No.12 (2025) , 847-857
Suggested Citation
Thanontip K., Chetsawang B., Siripornpanich V., Chumchua V., Chetsawang J. In Silico Study of Functional Network Analysis Focusing on Antipsychotic Drugs and Cognitive Function in Schizophrenia. Siriraj Medical Journal Vol.77 No.12 (2025) , 847-857. 857. doi:10.33192/smj.v77i12.277103 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113484
Title
In Silico Study of Functional Network Analysis Focusing on Antipsychotic Drugs and Cognitive Function in Schizophrenia
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Corresponding Author(s)
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Abstract
Objective: Recent evidence has emphasized cognitive dysfunction in psychiatric disorders. This study explores bioinformatics analysis aimed at investigating gene targets and pathways related to antipsychotic drug effects on cognitive function in schizophrenia. The main purpose of conventional antipsychotics is to treat the positive symptoms, but they have limited evidence for the involvement of these drugs in cognitive function. Therefore, this study aimed to explore the pathway for the antipsychotic signaling in the cognitive function of schizophrenia. Materials and Methods: Nine frequently used antipsychotics were included from the literature review. The GeneCards database was utilized to identify the drug target genes associated with cognitive function in schizophrenia. The gene lists were analyzed with two different tools, WebGestalt and STRING. The overlapping genes that result from the two previous steps may play an essential role in cognitive function. These genes were analyzed to find out the related pathway using the KEGG database. Results: The potential gene list consists of CHRM1, HRH3, DRD2, GRM5, HTR2A, and SLC6A1. The functional enrichment in KEGG reveals six target proteins involved in several pathways, which play an essential role in cognitive function, including the neuroactive ligand-receptor interaction, the gap junction, the calcium signaling pathway, and the cAMP signaling pathway. Conclusion: The results reveal that G-protein-coupled receptors (GPCRs) are the main target site of potential mechanisms or processes related to antipsychotics and cognitive function. Therefore, GPCRs might be a promising candidate for future research on potential therapeutic targets for intervention in neurological dysfunction-associated cognitive deficits in schizophrenia.