The evolving role of tissue-resident memory T cells in infections and cancer
Issued Date
2022-08-19
Resource Type
eISSN
23752548
Scopus ID
2-s2.0-85136000404
Pubmed ID
35977028
Journal Title
Science Advances
Volume
8
Issue
33
Rights Holder(s)
SCOPUS
Bibliographic Citation
Science Advances Vol.8 No.33 (2022)
Suggested Citation
Yenyuwadee S., Sanchez-Trincado Lopez J.L., Shah R., Rosato P.C., Boussiotis V.A. The evolving role of tissue-resident memory T cells in infections and cancer. Science Advances Vol.8 No.33 (2022). doi:10.1126/sciadv.abo5871 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86483
Title
The evolving role of tissue-resident memory T cells in infections and cancer
Other Contributor(s)
Abstract
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in tissues. TRM form an integral part of the immune sensing network and have the ability to control local immune homeostasis and participate in immune responses mediated by pathogens, cancer, and possibly autoantigens during autoimmunity. TRM express residence gene signatures, functional properties of both memory and effector cells, and remarkable plasticity. TRM have a well-established role in pathogen immunity, whereas their role in antitumor immune responses and immunotherapy is currently evolving. As TRM form the most abundant T memory cell population in nonlymphoid tissues, they are attractive targets for therapeutic exploitation. Here, we provide a concise review of the development and physiological role of CD8+ TRM, their involvement in diseases, and their potential therapeutic exploitation.