Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions
Issued Date
2022-05-01
Resource Type
eISSN
20794991
Scopus ID
2-s2.0-85129947596
Journal Title
Nanomaterials
Volume
12
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nanomaterials Vol.12 No.10 (2022)
Suggested Citation
Thanasrisuebwong P., Jones J.R., Eiamboonsert S., Ruangsawasdi N., Jirajariyavej B., Naruphontjirakul P. Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions. Nanomaterials Vol.12 No.10 (2022). doi:10.3390/nano12101691 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85084
Title
Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions
Other Contributor(s)
Abstract
Zn-containing dense monodispersed bioactive glass nanoparticles (Zn-BAGNPs) have been developed to deliver therapeutic inorganic trace elements, including Si, Ca, Sr, and Zn, to the cells through the degradation process, as delivery carriers for stimulating bone regeneration because of their capacity to induce osteogenic differentiation. The sol–gel-derived dense silica nanoparticles (SiO2-NPs) were first synthesized using the modified Stöber method, prior to incorporating therapeutic cations through the heat treatment process. The successfully synthesized monodispersed Zn-BAGNPs (diameter of 130 ± 20 nm) were homogeneous in size with spherical morphology. Ca, Sr and Zn were incorporated through the two-step post-functionalization process, with the nominal ZnO ratio between 0 and 2 (0, 0.5, 1.0, 1.5 and 2.0). Zn-BAGNPs have the capacity for continuous degradation and simultaneous ion release in SBF and PBS solutions due to their amorphous structure. Zn-BAGNPs have no in vitro cytotoxicity on the murine pre-osteoblast cell (MC3T3-E1) and periodontal ligament stem cells (PDLSCs), up to a concentration of 250 µg/mL. Zn-BAGNPs also stimulated osteogenic differentiation on PDLSCs treated with particles, after 2 and 3 weeks in culture. Zn-BAGNPs were not toxic to the cells and have the potential to stimulate osteogenic differentiation on PDLSCs. Therefore, Zn-BAGNPs are potential vehicles for therapeutic cation delivery for applications in bone and dental regenerations.