Isolation and structure elucidation of secondary metabolites from the fruiting bodies of Pleurotus citrinopileatus Singer and evaluation of lipase inhibitory and anti-lipid accumulation activities
3
Issued Date
2026-01-01
Resource Type
ISSN
14786419
eISSN
14786427
Scopus ID
2-s2.0-105033197491
Journal Title
Natural Product Research
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Research (2026)
Suggested Citation
Thongkongkaew T., Laowittawat C., Jitrapakdee S., Ruchirawat S. Isolation and structure elucidation of secondary metabolites from the fruiting bodies of Pleurotus citrinopileatus Singer and evaluation of lipase inhibitory and anti-lipid accumulation activities. Natural Product Research (2026). doi:10.1080/14786419.2026.2645752 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115882
Title
Isolation and structure elucidation of secondary metabolites from the fruiting bodies of Pleurotus citrinopileatus Singer and evaluation of lipase inhibitory and anti-lipid accumulation activities
Corresponding Author(s)
Other Contributor(s)
Abstract
The edible mushroom Pleurotus citrinopileatus Singer contains bioactive compounds that may be used for the management of obesity. Despite extensive research, secondary metabolites with lipase inhibition and suppression of lipid accumulation remain unexplored. Herein, we report the isolation, structure elucidation, and biological evaluation of secondary metabolites from the fruiting bodies of P. citrinopileatus. Based on spectroscopic analysis and a comparison with spectroscopic data reported in the literatures, six compounds were identified: ergosterol (1), cerevisterol (2), uracil (3), a diastereomeric mixture of 5′-deoxy-5′-methylaminoadenosine (4), diethylene glycol monobutyl ether (5), and tryptophan (6). Compounds 1–6 showed mild lipase inhibitory activity ranging from 1.7 to 11.3%. In contrast to a previous report, ergosterol 1 did not inhibit lipid accumulation in 3T3-L1 adipocytes at 25, 50, and 75 µM. This finding provides valuable insight about secondary metabolites from the fruiting bodies of this mushroom and reports their lipase inhibitory and anti-lipid accumulation activities.