Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity
9
Issued Date
2025-01-01
Resource Type
ISSN
00320943
eISSN
14390221
Scopus ID
2-s2.0-105005148399
Pubmed ID
40239717
Journal Title
Planta Medica
Rights Holder(s)
SCOPUS
Bibliographic Citation
Planta Medica (2025)
Suggested Citation
Liangsakul P., Kuhakarn C., Jungsuttiwong S., Intayot R., Thanasansurapong S., Akkarawongsapat R., Chairoungdua A., Nuntasaen N., Hongthong S., Reutrakul V. Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity. Planta Medica (2025). doi:10.1055/a-2589-5900 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110359
Title
Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity
Corresponding Author(s)
Other Contributor(s)
Abstract
Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1 and 2) and a xanthone (ventilagoxanthone, 3), along with eight known compounds (4 - 11), were isolated from the bark of Ventilago maingayi. Their structures were elucidated by extensive analysis of their spectroscopic data and by comparison with those of related compounds reported in the literature. The absolute configuration of ventilaganone A (1) was established by single-crystal X-ray analysis. Anti-HIV-1 activity of the isolated compounds was evaluated with a reverse transcriptase (RT) assay and a syncytium reduction assay using the ΔTat/Rev MC99 virus in the 1A2 cell line. Compounds 1, 2, 4, 5, and 8-11 showed inhibitory activity against syncytium formation, while most compounds were found to be inactive in the reverse transcriptase assay.