Extraction, physicochemical characterization, functionality, and excipient ability of corn fiber gum-starch isolate from corn milling industry waste
Issued Date
2023-10-15
Resource Type
ISSN
03785173
eISSN
18733476
Scopus ID
2-s2.0-85171768353
Pubmed ID
37696343
Journal Title
International Journal of Pharmaceutics
Volume
645
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics Vol.645 (2023)
Suggested Citation
Deokar G.S., Deokar A.M., Kshirsagar S.J., Buranasompob A., Nirmal N.P. Extraction, physicochemical characterization, functionality, and excipient ability of corn fiber gum-starch isolate from corn milling industry waste. International Journal of Pharmaceutics Vol.645 (2023). doi:10.1016/j.ijpharm.2023.123401 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90247
Title
Extraction, physicochemical characterization, functionality, and excipient ability of corn fiber gum-starch isolate from corn milling industry waste
Author's Affiliation
Other Contributor(s)
Abstract
Corn processing industries generate an extensive fibrous byproduct consisting of corn fiber gum (CFG) and residual starch (S). The present study hypothesized that CFG and S could be isolated as a single crosslinked conjugate. The isolated CFG-S conjugate was acidic, with a pKa value of 11.49, and a swelling index of 99.60%. Henderson–Hasselbalch equation predicted negligible ionization throughout the gastrointestinal pH range. The DSC thermogram highlights glass transition and temperature-specific structure stabilization through the exothermic crystallization domain. FTIR, SEM & XRD confirmed the structural conjugation and integrity of the conjugate. Tablets containing Venlafaxine hydrochloride as a model drug were prepared using CFG-S (14 and 57%) as excipient by wet granulation method. Percentage cumulative drug release with low concentration was up to 99.67175 ± 0.09 % in 5 h whereas with high concentration, it was extended to 12 h (P < 0.05). Korsemayer-Peppas release exponent indicates zero order (R2 = 0.9935) kinetics with super case-II anomalous transport showing diffusion and erosion as drug release mechanisms. The results confirmed that CFG-S isolate could act as a good binding agent at low concentrations and release extending cross-linked matrix former at a higher concentration for release retardant excipient.