Undifferentiated Pleomorphic Sarcoma with Reactive Eccrine Syringofibroadenoma: A Case Report
Issued Date
2024-12-01
Resource Type
eISSN
22963529
Scopus ID
2-s2.0-105018864723
Journal Title
Dermatopathology
Volume
11
Issue
4
Start Page
286
End Page
292
Rights Holder(s)
SCOPUS
Bibliographic Citation
Dermatopathology Vol.11 No.4 (2024) , 286-292
Suggested Citation
Donsakul N., Jerasutus S., Tubtieng I., Assavanatenapa R., Vejjabhinanta V. Undifferentiated Pleomorphic Sarcoma with Reactive Eccrine Syringofibroadenoma: A Case Report. Dermatopathology Vol.11 No.4 (2024) , 286-292. 292. doi:10.3390/dermatopathology11040030 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112732
Title
Undifferentiated Pleomorphic Sarcoma with Reactive Eccrine Syringofibroadenoma: A Case Report
Corresponding Author(s)
Other Contributor(s)
Abstract
Undifferentiated pleomorphic sarcoma (UPS) is an aggressive soft tissue sarcoma with a poor prognosis. The patients are usually found to have metastasis when the primary tumor is diagnosed. Eccrine syringofibroadenoma (ESFA) is a rare cutaneous adnexal lesion of eccrine duct origin. There are five subtypes, one of which is reactive ESFA, known to occur in reaction to an inflammatory or neoplastic process. In this article, we report a case of the co-existence of both UPS and ESFA in a 70-year-old male patient, presenting with a painless, erythematous, irregular surface nodule with a peripherally extended brownish hyperkeratotic plaque on the right palm. The histologic findings revealed an ill-defined dermal tumor of atypical epithelioid and spindle-shaped cells with large pleomorphic hyperchromatic nuclei and abundant eosinophilic cytoplasm. Some of those cells were multinucleated giant cells in the stroma with vascular proliferation and mixed inflammatory cell infiltrate. The tumor cells, which were only positive for vimentin, supported the diagnosis of undifferentiated pleomorphic sarcoma (UPS). Meanwhile, the overlying epidermis demonstrated hyperkeratosis, papillated epidermal hyperplasia, and proliferation of anastomosing slender cords and strands of cuboid cells within loose fibrovascular stroma. These findings are the characteristics of eccrine syringofibroadenoma (ESFA). We describe here a patient in whom reactive ESFA occurred on and surrounded the UPS tumor.