The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
Issued Date
2022-12-01
Resource Type
eISSN
20411723
Scopus ID
2-s2.0-85124679652
Pubmed ID
35169114
Journal Title
Nature Communications
Volume
13
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Communications Vol.13 No.1 (2022)
Suggested Citation
Abdelnabi R., Foo C.S., Jochmans D., Vangeel L., De Jonghe S., Augustijns P., Mols R., Weynand B., Wattanakul T., Hoglund R.M., Tarning J., Mowbray C.E., Sjö P., Escudié F., Scandale I., Chatelain E., Neyts J. The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern. Nature Communications Vol.13 No.1 (2022). doi:10.1038/s41467-022-28354-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84142
Title
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
Author's Affiliation
Other Contributor(s)
Abstract
There is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer developed PF-07321332 (PF-332), a potent inhibitor of the viral main protease (Mpro, 3CLpro) that can be dosed orally and that is in clinical development. We here report that PF-332 exerts equipotent in vitro activity against the four SARS-CoV-2 variants of concerns (VoC) and that it can completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface. Treatment of Syrian Golden hamsters with PF-332 (250 mg/kg, twice daily) completely protected the animals against intranasal infection with the beta (B.1.351) and delta (B.1.617.2) SARS-CoV-2 variants. Moreover, treatment of SARS-CoV-2 (B.1.617.2) infected animals with PF-332 completely prevented transmission to untreated co-housed sentinels.