Familial Dyskeratotic Comedones: A Case Report and Literature Review
Issued Date
2023-01-01
Resource Type
eISSN
11787015
Scopus ID
2-s2.0-85164373884
Journal Title
Clinical, Cosmetic and Investigational Dermatology
Volume
16
Start Page
1729
End Page
1735
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical, Cosmetic and Investigational Dermatology Vol.16 (2023) , 1729-1735
Suggested Citation
Tejapira K., Suchonwanit P. Familial Dyskeratotic Comedones: A Case Report and Literature Review. Clinical, Cosmetic and Investigational Dermatology Vol.16 (2023) , 1729-1735. 1735. doi:10.2147/CCID.S420723 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88030
Title
Familial Dyskeratotic Comedones: A Case Report and Literature Review
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Familial dyskeratotic comedones (FDC) is an autosomal dominant inherited skin disorder characterized by generalized multiple discrete comedone-like hyperkeratotic papules. The disease demonstrates a distinct histopathologic feature of dyskeratosis of the crater-like invaginated epidermis or follicle-like structures with or without acantholysis. Despite its asymptomatic and benign course, the condition is refractory to treatment. Herein, we report a case of a 54-year-old female presenting with progressively developed generalized multiple hyperkeratotic papules with central keratin plugs on the trunk and extremities for 20 years. A definite diagnosis was made by clinical manifestations and histopathological examination. The lesions were slightly improved after 3 months of topical retinoids and urea cream treatments. Besides, we first describe dermoscopic findings of FDC and reviewed 21 previously reported FDC cases from 11 families in the literature.