Neodolastane diterpenoids from cultures of basidiomycete hydropus cf. trichoderma
Issued Date
2026-10-01
Resource Type
ISSN
00319422
eISSN
18733700
Scopus ID
2-s2.0-105038940496
Journal Title
Phytochemistry
Volume
250
Rights Holder(s)
SCOPUS
Bibliographic Citation
Phytochemistry Vol.250 (2026)
Suggested Citation
Yangchum A., Pruksatrakul T., Sappan M., Srichomthong K., Boonpratuang T., Doloh W., Surawatanawong P., Isaka M. Neodolastane diterpenoids from cultures of basidiomycete hydropus cf. trichoderma. Phytochemistry Vol.250 (2026). doi:10.1016/j.phytochem.2026.114973 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116876
Title
Neodolastane diterpenoids from cultures of basidiomycete hydropus cf. trichoderma
Corresponding Author(s)
Other Contributor(s)
Abstract
A highly conjugated 17- nor -neodolastane diterpenoid possessing a nitrile group, hydropusin A ( 1 ), and a neodolastane, hydropusin B ( 2a / 2 b / 2c ), were isolated from cultures of the basidiomycete Hydropus cf. Trichoderma TBRC-BCC 43790. Hydropusin B was isolated as a mixture of three forms of interconvertible isomerization, which was supported by a deuteration experiment. Hydropusin A exhibited weak cytotoxicity to NCI–H187 and Vero cell-lines (IC<inf>50</inf> 60.6 and 64.5 μM, respectively), whereas hydropusin B showed antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC 12.5 μg/mL).