Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus
Issued Date
2024-01-01
Resource Type
ISSN
00916749
eISSN
10976825
Scopus ID
2-s2.0-85193505596
Pubmed ID
38670233
Journal Title
Journal of Allergy and Clinical Immunology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Allergy and Clinical Immunology (2024)
Suggested Citation
Reshef A., Buttgereit T., Betschel S.D., Caballero T., Farkas H., Grumach A.S., Hide M., Jindal A.K., Longhurst H., Peter J., Riedl M.A., Zhi Y., Aberer W., Abuzakouk M., Al Farsi T., Al Sukaiti N., Al-Ahmad M., Altrichter S., Aygören-Pürsün E., Baeza M.L., Bara N.A., Bauer A., Bernstein J.A., Boccon-Gibod I., Bonnekoh H., Bouillet L., Brzoza Z., Bygum A., Calderon O., de Albuquerque Campos R., Campos Romero F.H., Cancian M., Chong-Neto H.J., Christoff G., Cimbollek S., Cohn D.M., Craig T., Danilycheva I., Darlenski R., Du-Thanh A., Ensina L.F., Fomina D., Fonacier L., Fukunaga A., Gelincik A., Giavina-Bianchi P., Godse K., Gompels M., Goncalo M., Gotua M., Guidos-Fogelbach G., Guilarte M., Kasperska-Zajac A., Katelaris C.H., Kinaciyan T., Kolkhir P., Kulthanan K., Kurowski M., Latysheva E., Lauerma A., Launay D., Lleonart R., Lumry W., Malbran A., Ali R.M., Nasr I., Nieto-Martinez S., Parisi C., Pawankar R., Piñero-Saavedra M., Popov T.A., Porebski G., Prieto Garcia A., Pyatilova P., Rudenko M., Sekerel B.E., Serpa F.S., Sheikh F., Siebenhaar F., Soria A., Staevska M., Staubach P., Stobiecki M., Thomsen S.F., Triggiani M., Valerieva A., Valle S., Van Dinh N., Vera Ayala C.E., Zalewska-Janowska A., Zanichelli A., Magerl M., Maurer M. Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus. Journal of Allergy and Clinical Immunology (2024). doi:10.1016/j.jaci.2024.03.024 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/98509
Title
Definition, acronyms, nomenclature, and classification of angioedema (DANCE): AAAAI, ACAAI, ACARE, and APAAACI DANCE consensus
Author(s)
Reshef A.
Buttgereit T.
Betschel S.D.
Caballero T.
Farkas H.
Grumach A.S.
Hide M.
Jindal A.K.
Longhurst H.
Peter J.
Riedl M.A.
Zhi Y.
Aberer W.
Abuzakouk M.
Al Farsi T.
Al Sukaiti N.
Al-Ahmad M.
Altrichter S.
Aygören-Pürsün E.
Baeza M.L.
Bara N.A.
Bauer A.
Bernstein J.A.
Boccon-Gibod I.
Bonnekoh H.
Bouillet L.
Brzoza Z.
Bygum A.
Calderon O.
de Albuquerque Campos R.
Campos Romero F.H.
Cancian M.
Chong-Neto H.J.
Christoff G.
Cimbollek S.
Cohn D.M.
Craig T.
Danilycheva I.
Darlenski R.
Du-Thanh A.
Ensina L.F.
Fomina D.
Fonacier L.
Fukunaga A.
Gelincik A.
Giavina-Bianchi P.
Godse K.
Gompels M.
Goncalo M.
Gotua M.
Guidos-Fogelbach G.
Guilarte M.
Kasperska-Zajac A.
Katelaris C.H.
Kinaciyan T.
Kolkhir P.
Kulthanan K.
Kurowski M.
Latysheva E.
Lauerma A.
Launay D.
Lleonart R.
Lumry W.
Malbran A.
Ali R.M.
Nasr I.
Nieto-Martinez S.
Parisi C.
Pawankar R.
Piñero-Saavedra M.
Popov T.A.
Porebski G.
Prieto Garcia A.
Pyatilova P.
Rudenko M.
Sekerel B.E.
Serpa F.S.
Sheikh F.
Siebenhaar F.
Soria A.
Staevska M.
Staubach P.
Stobiecki M.
Thomsen S.F.
Triggiani M.
Valerieva A.
Valle S.
Van Dinh N.
Vera Ayala C.E.
Zalewska-Janowska A.
Zanichelli A.
Magerl M.
Maurer M.
Buttgereit T.
Betschel S.D.
Caballero T.
Farkas H.
Grumach A.S.
Hide M.
Jindal A.K.
Longhurst H.
Peter J.
Riedl M.A.
Zhi Y.
Aberer W.
Abuzakouk M.
Al Farsi T.
Al Sukaiti N.
Al-Ahmad M.
Altrichter S.
Aygören-Pürsün E.
Baeza M.L.
Bara N.A.
Bauer A.
Bernstein J.A.
Boccon-Gibod I.
Bonnekoh H.
Bouillet L.
Brzoza Z.
Bygum A.
Calderon O.
de Albuquerque Campos R.
Campos Romero F.H.
Cancian M.
Chong-Neto H.J.
Christoff G.
Cimbollek S.
Cohn D.M.
Craig T.
Danilycheva I.
Darlenski R.
Du-Thanh A.
Ensina L.F.
Fomina D.
Fonacier L.
Fukunaga A.
Gelincik A.
Giavina-Bianchi P.
Godse K.
Gompels M.
Goncalo M.
Gotua M.
Guidos-Fogelbach G.
Guilarte M.
Kasperska-Zajac A.
Katelaris C.H.
Kinaciyan T.
Kolkhir P.
Kulthanan K.
Kurowski M.
Latysheva E.
Lauerma A.
Launay D.
Lleonart R.
Lumry W.
Malbran A.
Ali R.M.
Nasr I.
Nieto-Martinez S.
Parisi C.
Pawankar R.
Piñero-Saavedra M.
Popov T.A.
Porebski G.
Prieto Garcia A.
Pyatilova P.
Rudenko M.
Sekerel B.E.
Serpa F.S.
Sheikh F.
Siebenhaar F.
Soria A.
Staevska M.
Staubach P.
Stobiecki M.
Thomsen S.F.
Triggiani M.
Valerieva A.
Valle S.
Van Dinh N.
Vera Ayala C.E.
Zalewska-Janowska A.
Zanichelli A.
Magerl M.
Maurer M.
Author's Affiliation
David Tvildiani Medical University
Centro Hospitalar Universitário do Algarve
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Osaka Medical and Pharmaceutical University
Kepler Universitätsklinikum
Cleveland Clinic Abu Dhabi
Moscow Healthcare Department
NYU Grossman Long Island School of Medicine
Vall d'Hebron Institut de Recerca
Instituto de Investigación Sanitaria Gregorio Marañón
Instituto de Investigación Sanitaria del Hospital Universitario La Paz
Université de Lille
Skin and Allergy Hospital
University of Cape Town Lung Institute
State Research Center Institute of Immunology FMBA
Hamad Medical Corporation
Royal Hospital
Pirogov Russian National Research Medical University (RNRMU)
Gruppo Ospedaliero San Donato
Medizinische Universität Wien Universitätsklinik für Dermatologie
Kuwait University
Hospital Universitario Virgen del Rocío
Centre Hospitalier Universitaire de Montpellier
Hiroshima University
University of California, San Diego
Medical University of Sofia
North Bristol NHS Trust
Slaski Uniwersytet Medyczny w Katowicach
Azienda Ospedale Università Padova
Hospital Central Sur de Alta Especialidad
Charité – Universitätsmedizin Berlin
Bispebjerg Hospital
Semmelweis Egyetem
Università degli Studi di Milano, Facoltà di Medicina e Chirurgia
Universitätsmedizin Mainz
Jagiellonian University Medical College
Hacettepe Üniversitesi
Instituto Politécnico Nacional
Syddansk Universitet
Centro Hospitalar e Universitário de Coimbra
Centro Universitário FMABC
Nippon Medical School
Western Sydney University
University of Cincinnati College of Medicine
St. Michael's Hospital, Toronto
Odense Universitetshospital
Universidade Federal do Parana
Universidade Federal de São Paulo
Hôpital Tenon
Universidade Federal da Bahia
Trakia University
İstanbul Tıp Fakültesi
Hospital Universitari de Bellvitge
University Hospital Alexandrovska
Universitätsklinikum Frankfurt
Peking Union Medical College Hospital
Instituto Universitario del Hospital Italiano de Buenos Aires
Universidade de São Paulo
Università degli Studi di Salerno
Medical University of Lodz
Medizinische Universität Graz
Centre Hospitalier Universitaire de Grenoble
The University of Auckland
Instituto Nacional de Pediatría
Uniwersytet Opolski
Dr. D.Y. Patil Medical College, Navi Mumbai
Universiteit van Amsterdam
Pennsylvania State University
Postgraduate Institute of Medical Education & Research, Chandigarh
Universidade Federal do Rio de Janeiro
Romanian Hereditary Angioedema Expertise Centre
Excelsior Medical Centre
Vinmec Healthcare System
Higher School of Sciences of Santa Casa de Misericórdia de Vitória
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
San Isidro
London Allergy and Immunology Centre
Barzilai University Medical Center
Chughtai Lab
AARA Research Center
French National Reference Centre for Angioedema (CREAK)
Asma e Inmunología Clínica
Centro Hospitalar Universitário do Algarve
Universitätsklinikum Carl Gustav Carus Dresden
Siriraj Hospital
Osaka Medical and Pharmaceutical University
Kepler Universitätsklinikum
Cleveland Clinic Abu Dhabi
Moscow Healthcare Department
NYU Grossman Long Island School of Medicine
Vall d'Hebron Institut de Recerca
Instituto de Investigación Sanitaria Gregorio Marañón
Instituto de Investigación Sanitaria del Hospital Universitario La Paz
Université de Lille
Skin and Allergy Hospital
University of Cape Town Lung Institute
State Research Center Institute of Immunology FMBA
Hamad Medical Corporation
Royal Hospital
Pirogov Russian National Research Medical University (RNRMU)
Gruppo Ospedaliero San Donato
Medizinische Universität Wien Universitätsklinik für Dermatologie
Kuwait University
Hospital Universitario Virgen del Rocío
Centre Hospitalier Universitaire de Montpellier
Hiroshima University
University of California, San Diego
Medical University of Sofia
North Bristol NHS Trust
Slaski Uniwersytet Medyczny w Katowicach
Azienda Ospedale Università Padova
Hospital Central Sur de Alta Especialidad
Charité – Universitätsmedizin Berlin
Bispebjerg Hospital
Semmelweis Egyetem
Università degli Studi di Milano, Facoltà di Medicina e Chirurgia
Universitätsmedizin Mainz
Jagiellonian University Medical College
Hacettepe Üniversitesi
Instituto Politécnico Nacional
Syddansk Universitet
Centro Hospitalar e Universitário de Coimbra
Centro Universitário FMABC
Nippon Medical School
Western Sydney University
University of Cincinnati College of Medicine
St. Michael's Hospital, Toronto
Odense Universitetshospital
Universidade Federal do Parana
Universidade Federal de São Paulo
Hôpital Tenon
Universidade Federal da Bahia
Trakia University
İstanbul Tıp Fakültesi
Hospital Universitari de Bellvitge
University Hospital Alexandrovska
Universitätsklinikum Frankfurt
Peking Union Medical College Hospital
Instituto Universitario del Hospital Italiano de Buenos Aires
Universidade de São Paulo
Università degli Studi di Salerno
Medical University of Lodz
Medizinische Universität Graz
Centre Hospitalier Universitaire de Grenoble
The University of Auckland
Instituto Nacional de Pediatría
Uniwersytet Opolski
Dr. D.Y. Patil Medical College, Navi Mumbai
Universiteit van Amsterdam
Pennsylvania State University
Postgraduate Institute of Medical Education & Research, Chandigarh
Universidade Federal do Rio de Janeiro
Romanian Hereditary Angioedema Expertise Centre
Excelsior Medical Centre
Vinmec Healthcare System
Higher School of Sciences of Santa Casa de Misericórdia de Vitória
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
San Isidro
London Allergy and Immunology Centre
Barzilai University Medical Center
Chughtai Lab
AARA Research Center
French National Reference Centre for Angioedema (CREAK)
Asma e Inmunología Clínica
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Angioedema (AE) manifests with intermittent, localized, self-limiting swelling of the subcutaneous and/or submucosal tissue. AE is heterogeneous, can be hereditary or acquired, may occur only once or be recurrent, may exhibit wheals or not, and may be due to mast cell mediators, bradykinin, or other mechanisms. Several different taxonomic systems are currently used, making it difficult to compare the results of studies, develop multicenter collaboration, and harmonize AE treatment. Objective: We developed a consensus on the definition, acronyms, nomenclature, and classification of AE (DANCE). Methods: The initiative involved 91 experts from 35 countries and was endorsed by 53 scientific and medical societies, and patient organizations. A consensus was reached by online discussion and voting using the Delphi process over a period of 16 months (June 2021 to November 2022). Results: The DANCE initiative resulted in an international consensus on the definition, classification, and terminology of AE. The new consensus classification features 5 types and endotypes of AE and a harmonized vocabulary of abbreviations/acronyms. Conclusion: The DANCE classification complements current clinical guidelines and expert consensus recommendations on the diagnostic assessment and treatment of AE. DANCE does not replace current clinical guidelines, and expert consensus algorithms and should not be misconstrued in a way that affects reimbursement of medicines prescribed by physicians using sound clinical judgment. We anticipate that this new AE taxonomy and nomenclature will harmonize and facilitate AE research and clinical studies, thereby improving patient care.