Drug-Induced Movement Disorders
Issued Date
2023-04-03
Resource Type
ISSN
02718235
eISSN
10989021
Scopus ID
2-s2.0-85152163236
Pubmed ID
36828011
Journal Title
Seminars in Neurology
Volume
43
Issue
1
Start Page
35
End Page
47
Rights Holder(s)
SCOPUS
Bibliographic Citation
Seminars in Neurology Vol.43 No.1 (2023) , 35-47
Suggested Citation
Pandey S. Drug-Induced Movement Disorders. Seminars in Neurology Vol.43 No.1 (2023) , 35-47. 47. doi:10.1055/s-0043-1763510 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/82167
Title
Drug-Induced Movement Disorders
Author(s)
Other Contributor(s)
Abstract
Drug-induced movement disorders (DIMDs) are most commonly associated with typical and atypical antipsychotics. However, other drugs such as antidepressants, antihistamines, antiepileptics, antiarrhythmics, and gastrointestinal drugs can also cause abnormal involuntary movements. Different types of movement disorders can also occur because of adverse drug reactions. Therefore, the important key to diagnosing DIMDs is a causal relationship between potential offending drugs and the occurrence of abnormal movements. The pathophysiology of DIMDs is not clearly understood; however, many cases of DIMDs are thought to exert adverse mechanisms of action in the basal ganglia. The treatment of some DIMDs is quite challenging, and removing the offending drugs may not be possible in some conditions such as withdrawing antipsychotics in the patient with partially or uncontrollable neuropsychiatric conditions. Future research is needed to understand the mechanism of DIMDs and the development of drugs with better side-effect profiles. This article reviews the phenomenology, diagnostic criteria, pathophysiology, and management of DIMDs.