The parasite intraerythrocytic cycle and human circadian cycle are coupled during malaria infection
Issued Date
2023-06-13
Resource Type
eISSN
10916490
Scopus ID
2-s2.0-85161137530
Pubmed ID
37279274
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume
120
Issue
24
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings of the National Academy of Sciences of the United States of America Vol.120 No.24 (2023)
Suggested Citation
Motta F.C., McGoff K., Moseley R.C., Cho C.Y., Kelliher C.M., Smith L.M., Ortiz M.S., Leman A.R., Campione S.A., Devos N., Chaorattanakawee S., Uthaimongkol N., Kuntawunginn W., Thongpiam C., Thamnurak C., Arsanok M., Wojnarski M., Vanchayangkul P., Boonyalai N., Smith P.L., Spring M.D., Jongsakul K., Chuang I., Harer J., Haase S.B. The parasite intraerythrocytic cycle and human circadian cycle are coupled during malaria infection. Proceedings of the National Academy of Sciences of the United States of America Vol.120 No.24 (2023). doi:10.1073/pnas.2216522120 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83056
Title
The parasite intraerythrocytic cycle and human circadian cycle are coupled during malaria infection
Author(s)
Motta F.C.
McGoff K.
Moseley R.C.
Cho C.Y.
Kelliher C.M.
Smith L.M.
Ortiz M.S.
Leman A.R.
Campione S.A.
Devos N.
Chaorattanakawee S.
Uthaimongkol N.
Kuntawunginn W.
Thongpiam C.
Thamnurak C.
Arsanok M.
Wojnarski M.
Vanchayangkul P.
Boonyalai N.
Smith P.L.
Spring M.D.
Jongsakul K.
Chuang I.
Harer J.
Haase S.B.
McGoff K.
Moseley R.C.
Cho C.Y.
Kelliher C.M.
Smith L.M.
Ortiz M.S.
Leman A.R.
Campione S.A.
Devos N.
Chaorattanakawee S.
Uthaimongkol N.
Kuntawunginn W.
Thongpiam C.
Thamnurak C.
Arsanok M.
Wojnarski M.
Vanchayangkul P.
Boonyalai N.
Smith P.L.
Spring M.D.
Jongsakul K.
Chuang I.
Harer J.
Haase S.B.
Author's Affiliation
University of California, San Francisco
Florida Atlantic University
Armed Forces Research Institute of Medical Sciences, Thailand
Walter Reed Army Institute of Research
Mahidol University
Duke University
Geisel School of Medicine at Dartmouth
The University of North Carolina at Charlotte
Walter Reed National Military Medical Center
Duke University School of Medicine
Geometric Data Analytics
Sana Biotechnology Inc.
LLC.
Florida Atlantic University
Armed Forces Research Institute of Medical Sciences, Thailand
Walter Reed Army Institute of Research
Mahidol University
Duke University
Geisel School of Medicine at Dartmouth
The University of North Carolina at Charlotte
Walter Reed National Military Medical Center
Duke University School of Medicine
Geometric Data Analytics
Sana Biotechnology Inc.
LLC.
Other Contributor(s)
Abstract
During infections with the malaria parasites Plasmodium vivax, patients exhibit rhythmic fevers every 48 h. These fever cycles correspond with the time the parasites take to traverse the intraerythrocytic cycle (IEC). In other Plasmodium species that infect either humans or mice, the IEC is likely guided by a parasite-intrinsic clock [Rijo-Ferreiraet al., Science368, 746-753 (2020); Smith et al., Science368, 754-759 (2020)], suggesting that intrinsic clock mechanisms may be a fundamental feature of malaria parasites. Moreover, because Plasmodium cycle times are multiples of 24 h, the IECs may be coordinated with the host circadian clock(s). Such coordination could explain the synchronization of the parasite population in the host and enable alignment of IEC and circadian cycle phases. We utilized an ex vivo culture of whole blood from patients infected with P. vivax to examine the dynamics of the host circadian transcriptome and the parasite IEC transcriptome. Transcriptome dynamics revealed that the phases of the host circadian cycle and the parasite IEC are correlated across multiple patients, showing that the cycles are phase coupled. In mouse model systems, host-parasite cycle coupling appears to provide a selective advantage for the parasite. Thus, understanding how host and parasite cycles are coupled in humans could enable antimalarial therapies that disrupt this coupling.