Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation
Issued Date
2024-02-06
Resource Type
eISSN
10916490
Scopus ID
2-s2.0-85183692375
Pubmed ID
38289950
Journal Title
Proceedings of the National Academy of Sciences of the United States of America
Volume
121
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
Proceedings of the National Academy of Sciences of the United States of America Vol.121 No.6 (2024)
Suggested Citation
Kline S.N., Orlando N.A., Lee A.J., Wu M.J., Zhang J., Youn C., Feller L.E., Pontaza C., Dikeman D., Limjunyawong N., Williams K.L., Wang Y., Cihakova D., Jacobsen E.A., Durum S.K., Garza L.A., Dong X., Archer N.K. Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation. Proceedings of the National Academy of Sciences of the United States of America Vol.121 No.6 (2024). doi:10.1073/pnas.2309243121 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97129
Title
Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation
Corresponding Author(s)
Other Contributor(s)
Abstract
Staphylococcus aureus skin colonization and eosinophil infiltration are associated with many inflammatory skin disorders, including atopic dermatitis, bullous pemphigoid, Netherton's syndrome, and prurigo nodularis. However, whether there is a relationship between S. aureus and eosinophils and how this interaction influences skin inflammation is largely undefined. We show in a preclinical mouse model that S. aureus epicutaneous exposure induced eosinophil-recruiting chemokines and eosinophil infiltration into the skin. Remarkably, we found that eosinophils had a comparable contribution to the skin inflammation as T cells, in a manner dependent on eosinophil-derived IL-17A and IL-17F production. Importantly, IL-36R signaling induced CCL7-mediated eosinophil recruitment to the inflamed skin. Last, S. aureus proteases induced IL-36α expression in keratinocytes, which promoted infiltration of IL-17-producing eosinophils. Collectively, we uncovered a mechanism for S. aureus proteases to trigger eosinophil-mediated skin inflammation, which has implications in the pathogenesis of inflammatory skin diseases.