Unraveling the drivers of leptospirosis risk in Thailand using machine learning
10
Issued Date
2025-10-01
Resource Type
eISSN
19352735
Scopus ID
2-s2.0-105019818472
Pubmed ID
41086238
Journal Title
Plos Neglected Tropical Diseases
Volume
19
Issue
10
Rights Holder(s)
SCOPUS
Bibliographic Citation
Plos Neglected Tropical Diseases Vol.19 No.10 (2025) , e0013618
Suggested Citation
Suttirat P., Chadsuthi S., Modchang C., Rocklöv J. Unraveling the drivers of leptospirosis risk in Thailand using machine learning. Plos Neglected Tropical Diseases Vol.19 No.10 (2025) , e0013618. doi:10.1371/journal.pntd.0013618 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112880
Title
Unraveling the drivers of leptospirosis risk in Thailand using machine learning
Author(s)
Corresponding Author(s)
Other Contributor(s)
Abstract
Leptospirosis poses a significant public health challenge in Thailand, driven by a complex mix of environmental and socioeconomic factors. This study develops an XGBoost machine learning model to predict leptospirosis outbreak risk at the provincial level in Thailand, integrating climatic, socioeconomic, and agricultural features. Using national surveillance data from 2007-2022, the model was trained to classify provinces as high or low risk based on the median incidence rate. The model's predictive performance was validated for the years 2018-2022, spanning pre-COVID-19, COVID-19, and post-COVID-19 periods. SHapley Additive exPlanation (SHAP) analysis was employed to identify key predictive factors. The optimized XGBoost model achieved high predictive accuracy for the pre-pandemic (AUC = 0.937 with 95% CI: 0.878 - 0.976) and post-pandemic (AUC = 0.951 with 95% CI: 0.861 - 0.999) testing periods. SHAP analysis revealed rice production factors, household size, and specific climatic variables as the strongest predictors of leptospirosis risk. However, model performance declined during the COVID-19 pandemic (2020-2021), suggesting surveillance disruption and potential underreporting. This study demonstrates the utility of machine learning for predicting leptospirosis risk in Thailand and highlights the complex interplay of environmental and socioeconomic factors in driving outbreaks. The adaptable modeling framework provides a foundation for developing early warning systems and targeted interventions to reduce the burden of this neglected tropical disease.