Long-Term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome/toxic epidermal necrolysis: A comparative study
Issued Date
2024-01-01
Resource Type
ISSN
00071161
eISSN
14682079
Scopus ID
2-s2.0-85188252938
Pubmed ID
38490716
Journal Title
British Journal of Ophthalmology
Rights Holder(s)
SCOPUS
Bibliographic Citation
British Journal of Ophthalmology (2024)
Suggested Citation
Rashad R., Kwan J.T., Shanbhag S.S., Ngowyutagon P., Saeed M., Tahboub M.A., Haseeb A., Chodosh J., Saeed H.N. Long-Term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome/toxic epidermal necrolysis: A comparative study. British Journal of Ophthalmology (2024). doi:10.1136/bjo-2023-324076 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97765
Title
Long-Term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome/toxic epidermal necrolysis: A comparative study
Corresponding Author(s)
Other Contributor(s)
Abstract
Purpose To compare the effectiveness and efficiency of a glued (sutureless) technique for amniotic membrane transplantation (AMT) with a traditional sutured one in the setting of acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Methods This retrospective cohort study evaluated all patients diagnosed with SJS/TEN between 2008 and 2020 within our hospital network who received AMT in the acute phase according to our protocol and had at least one ophthalmic follow-up in the chronic phase. Primary outcomes included best-corrected visual acuity (BCVA) at the most recent visit, presence of a severe ocular complication (SOC) via predefined criteria, time to procedure and duration of procedure. Random effects model analysis was used to evaluate the impact of potential covariates on outcome measures. Results A total of 23 patients (45 eyes) were included: 14 patients (27 eyes) in the AMT suture group and 9 patients (18 eyes) in the AMT glue group. There was no difference between the two groups in BCVA at the most recent visit (p=0.5112) or development of a SOC (p=1.000). The glue method was shorter in duration than the suture method (p0.001). Random effects model additionally indicated that there was no difference in BCVA at most recent follow-up between patients who had received glued versus sutured AMT (p=0.1460). Conclusions Our glued technique for AMT is as effective as our sutured technique in stabilising the ocular surface and mitigating chronic ocular complications in SJS/TEN. The glued technique is also shorter in duration and performed more expediently than the sutured technique.