Generation of integration-free human induced pluripotent stem cell line MUi040-A derived from CD34 + hematopoietic stem cells of a patient with constitutional pericentric inversion of chromosome 9
Issued Date
2025-12-01
Resource Type
ISSN
18735061
eISSN
18767753
Scopus ID
2-s2.0-105023870449
Pubmed ID
41223746
Journal Title
Stem Cell Research
Volume
89
Rights Holder(s)
SCOPUS
Bibliographic Citation
Stem Cell Research Vol.89 (2025)
Suggested Citation
Linn A.K., Phanthong P., Pewkliang Y., Laosee W., Tong-Ngam P., Tubsuwan A., Trachoo O., Asavapanumas N., Borwornpinyo S., Hongeng S., Yingchoncharoen T. Generation of integration-free human induced pluripotent stem cell line MUi040-A derived from CD34 + hematopoietic stem cells of a patient with constitutional pericentric inversion of chromosome 9. Stem Cell Research Vol.89 (2025). doi:10.1016/j.scr.2025.103866 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113477
Title
Generation of integration-free human induced pluripotent stem cell line MUi040-A derived from CD34 + hematopoietic stem cells of a patient with constitutional pericentric inversion of chromosome 9
Corresponding Author(s)
Other Contributor(s)
Abstract
The MUi040-A human induced pluripotent stem cell (hiPSC) line was established from CD34 + hematopoietic stem cells of a male patient with senile amyloidosis. Patient carries a unique chromosome inversion at bands 9p12 and 9q13, which is one of the most common variants of the normal karyotype of chromosome 9 (inv[9]). This hiPSC line maintains an identical karyotype to that of the parental cells. MUi040-A expressed pluripotency markers and demonstrated the capacity to differentiate into all three germ layers. This cell line offers a valuable in vitro for studying the pathophysiology of senile systemic amyloidosis and for evaluating potential therapeutic approaches.