Recurrent chronic spontaneous urticaria in a tropical country: Clinical characteristics and associated factors
Issued Date
2025-09-01
Resource Type
ISSN
0125877X
eISSN
22288694
Scopus ID
2-s2.0-105020779134
Pubmed ID
40321140
Journal Title
Asian Pacific Journal of Allergy and Immunology
Volume
43
Issue
3
Start Page
513
End Page
520
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology Vol.43 No.3 (2025) , 513-520
Suggested Citation
Limphoka P., Jiamton S., Chularojanamontri L., Kulthanan K., Tuchinda P. Recurrent chronic spontaneous urticaria in a tropical country: Clinical characteristics and associated factors. Asian Pacific Journal of Allergy and Immunology Vol.43 No.3 (2025) , 513-520. 520. doi:10.12932/ap-261124-1984 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113035
Title
Recurrent chronic spontaneous urticaria in a tropical country: Clinical characteristics and associated factors
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Corresponding Author(s)
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Abstract
Background: Limited data exist regarding recurrent chronic spontaneous urticaria (RCSU) following complete disease remission. Objective: This study investigated the clinical characteristics and factors associated with RCSU. Methods: We retrospectively reviewed data from chronic spontaneous urticaria (CSU) patients who actively visited the Urticaria Center of Reference and Excellence, Siriraj Hospital, between January 2021 and December 2023. Medical records were analyzed through May 2024. The RCSU was defined as a new CSU episode occurring after a 6-month symptom-free period without treatment. Results: Among 179 CSU patients, 19 (10.6%) developed RCSU. These patients had a mean age of 40 (SD 14.9) years, with a female predominance. The mean time to RCSU recurrence was 1.96 (SD 2.05) years. The UAS7 and medication scores were not significantly different between the recurrence and nonrecurrence groups (P = 0.675, P = 0.77). Multivariate analysis revealed that a shorter disease remission time from the first episode onset (< 3 years) was significantly associated with RCSU (odds ratio 5.13, 95%CI 1.83‒14.29; P = 0.002). Conclusion: The RCSU rate was 10.6%. The time to disease remission from the first episode onset significantly associated with RCSU. Several clinical characteristics may corelate with the recurrence: younger age at onset, the presence of angioedema, chronic inducible urticaria comorbidity, systemic corticosteroid use, and positive antinuclear antibody status.