Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
Issued Date
2022-07-15
Resource Type
ISSN
00221899
eISSN
15376613
Scopus ID
2-s2.0-85137126581
Pubmed ID
35703955
Journal Title
Journal of Infectious Diseases
Volume
226
Issue
2
Start Page
324
End Page
331
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases Vol.226 No.2 (2022) , 324-331
Suggested Citation
Cutts J.C., O’Flaherty K., Zaloumis S.G., Ashley E.A., Chan J.A., Onyamboko M.A., Fanello C., Dondorp A.M., Day N.P., Phyo A.P., Dhorda M., Imwong M., Fairhurst R.M., Lim P., Amaratunga C., Pukrittayakamee S., Hien T.T., Htut Y., Mayxay M., Abdul Faiz M., Takashima E., Tsuboi T., Beeson J.G., Nosten F., Simpson J.A., White N.J., Fowkes F.J.I. Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia. Journal of Infectious Diseases Vol.226 No.2 (2022) , 324-331. 331. doi:10.1093/infdis/jiac232 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85715
Title
Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
Author(s)
Cutts J.C.
O’Flaherty K.
Zaloumis S.G.
Ashley E.A.
Chan J.A.
Onyamboko M.A.
Fanello C.
Dondorp A.M.
Day N.P.
Phyo A.P.
Dhorda M.
Imwong M.
Fairhurst R.M.
Lim P.
Amaratunga C.
Pukrittayakamee S.
Hien T.T.
Htut Y.
Mayxay M.
Abdul Faiz M.
Takashima E.
Tsuboi T.
Beeson J.G.
Nosten F.
Simpson J.A.
White N.J.
Fowkes F.J.I.
O’Flaherty K.
Zaloumis S.G.
Ashley E.A.
Chan J.A.
Onyamboko M.A.
Fanello C.
Dondorp A.M.
Day N.P.
Phyo A.P.
Dhorda M.
Imwong M.
Fairhurst R.M.
Lim P.
Amaratunga C.
Pukrittayakamee S.
Hien T.T.
Htut Y.
Mayxay M.
Abdul Faiz M.
Takashima E.
Tsuboi T.
Beeson J.G.
Nosten F.
Simpson J.A.
White N.J.
Fowkes F.J.I.
Author's Affiliation
WorldWide Antimalarial Resistance Network
Faculty of Tropical Medicine, Mahidol University
Mahidol Oxford Tropical Medicine Research Unit
Oxford University Clinical Research Unit
Melbourne School of Population and Global Health
The Peter Doherty Institute for Infection and Immunity
Ministry of Health Myanmar
Shoklo Malaria Research Unit
Monash University
National Institute of Allergy and Infectious Diseases (NIAID)
Mahosot Hospital, Lao
Faculty of Medicine, Nursing and Health Sciences
Nuffield Department of Medicine
Burnet Institute
Ehime University
University of Health Sciences
Myanmar Oxford Clinical Research Unit
Dev Care Foundation
Kinshasa School of Public Health
Faculty of Tropical Medicine, Mahidol University
Mahidol Oxford Tropical Medicine Research Unit
Oxford University Clinical Research Unit
Melbourne School of Population and Global Health
The Peter Doherty Institute for Infection and Immunity
Ministry of Health Myanmar
Shoklo Malaria Research Unit
Monash University
National Institute of Allergy and Infectious Diseases (NIAID)
Mahosot Hospital, Lao
Faculty of Medicine, Nursing and Health Sciences
Nuffield Department of Medicine
Burnet Institute
Ehime University
University of Health Sciences
Myanmar Oxford Clinical Research Unit
Dev Care Foundation
Kinshasa School of Public Health
Other Contributor(s)
Abstract
Background. Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southeast Asia, where resistance has emerged, P. falciparum antibodies confound parasite clearance measures. However, variation in naturally acquired antibodies across Asian and sub-Saharan African epidemiological contexts and their impact on parasite clearance re yet to be quantified. Methods. In an artemisinin therapeutic efficacy study, antibodies to 12 pre-erythrocytic and erythrocytic P. falciparum antigens were measured in 118 children with uncomplicated P. falciparum malaria in the Democratic Republic of Congo (DRC) and compared with responses in patients from Asian sites, described elsewhere. Results. Parasite clearance half-life was shorter in DRC patients (median, 2 hours) compared with most Asian sites (median, 2–7 hours), but P. falciparum antibody levels and seroprevalences were similar. There was no evidence for an association between antibody seropositivity and parasite clearance half-life (mean difference between seronegative and seropositive, −0.14 to +0.40 hour) in DRC patients. Conclusions. In DRC, where artemisinin remains highly effective, the substantially shorter parasite clearance time compared with Asia was not explained by differences in the P. falciparum antibody responses studied.