Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Issued Date
2023-12-01
Resource Type
ISSN
14747596
eISSN
1474760X
Scopus ID
2-s2.0-85171808539
Pubmed ID
37730643
Journal Title
Genome Biology
Volume
24
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Genome Biology Vol.24 No.1 (2023)
Suggested Citation
Deviatiiarov R., Nagai H., Ismagulov G., Stupina A., Wada K., Ide S., Toji N., Zhang H., Sukparangsi W., Intarapat S., Gusev O., Sheng G. Dosage compensation of Z sex chromosome genes in avian fibroblast cells. Genome Biology Vol.24 No.1 (2023). doi:10.1186/s13059-023-03055-z Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/90255
Title
Dosage compensation of Z sex chromosome genes in avian fibroblast cells
Other Contributor(s)
Abstract
In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensation and its role in sex specification, we use a highly quantitative method and analyze transcriptional activities of male and female fibroblast cells from seven bird species. Our data indicate that three fourths of chrZ genes are strictly compensated across Aves, similar to mammalian chrX. We also present a complete list of non-compensated chrZ genes and identify Ribosomal Protein S6 (RPS6) as a conserved sex-dimorphic gene in birds.