Medical management of pediatric inflammatory bowel disease in the Asia-Pacific region: A position paper by the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group
Issued Date
2023-04-01
Resource Type
ISSN
08159319
eISSN
14401746
Scopus ID
2-s2.0-85146229107
Pubmed ID
36574956
Journal Title
Journal of Gastroenterology and Hepatology (Australia)
Volume
38
Issue
4
Start Page
523
End Page
538
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Gastroenterology and Hepatology (Australia) Vol.38 No.4 (2023) , 523-538
Suggested Citation
Lee W.S., Arai K., Alex G., Treepongkaruna S., Kim K.M., Choong C.L., Mercado K.S.C., Darma A., Srivastava A., Aw M.M., Huang J., Ni Y.H., Malik R., Tanpowpong P., Tran H.N., Ukarapol N. Medical management of pediatric inflammatory bowel disease in the Asia-Pacific region: A position paper by the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group. Journal of Gastroenterology and Hepatology (Australia) Vol.38 No.4 (2023) , 523-538. 538. doi:10.1111/jgh.16097 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82098
Title
Medical management of pediatric inflammatory bowel disease in the Asia-Pacific region: A position paper by the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group
Author's Affiliation
National Center for Child Health and Development
Makati Medical Center
Children's Hospital No. 1 Ho Chi Minh City
Universitas Airlangga
Asan Medical Center
Faculty of Medicine, Chiang Mai University
National University Hospital
Universiti Malaya
NUS Yong Loo Lin School of Medicine
Royal Children's Hospital, Melbourne
National Taiwan University College of Medicine
Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
Faculty of Medicine Ramathibodi Hospital, Mahidol University
All India Institute of Medical Sciences, New Delhi
Makati Medical Center
Children's Hospital No. 1 Ho Chi Minh City
Universitas Airlangga
Asan Medical Center
Faculty of Medicine, Chiang Mai University
National University Hospital
Universiti Malaya
NUS Yong Loo Lin School of Medicine
Royal Children's Hospital, Melbourne
National Taiwan University College of Medicine
Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow
Faculty of Medicine Ramathibodi Hospital, Mahidol University
All India Institute of Medical Sciences, New Delhi
Other Contributor(s)
Abstract
Pediatric inflammatory bowel disease (PIBD) is rising rapidly in many industrialized and affluent areas in the Asia-Pacific region. Current available guidelines, mainly from Europe and North America, may not be completely applicable to clinicians caring for children with PIBD in this region due to differences in disease characteristics and regional resources constraints. This position paper is an initiative from the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition (APPSPGHAN) with the aim of providing an up-to-date, evidence-based approach to PIBD in the Asia-Pacific region, taking into consideration the unique disease characteristics and financial resources available in this region. A group of pediatric gastroenterologists with special interest in PIBD performed an extensive literature search covering epidemiology, disease characteristics and natural history, management, and monitoring. Gastrointestinal infections, including tuberculosis, need to be excluded before diagnosing IBD. In some populations in Asia, the Nudix Hydrolase 15 (NUD15) gene is a better predictor of leukopenia induced by azathioprine than thiopurine-S-methyltransferase (TPMT). The main considerations in the use of biologics in the Asia-Pacific region are high cost, ease of access, and potential infectious risk, especially tuberculosis. This position paper provides a useful guide to clinicians in the medical management of children with PIBD in the Asia-Pacific region.