Dynamic Eye Closure Restoration in Facial Palsy with Neurotized Platysma Muscle Graft in Rats
Issued Date
2024-01-01
Resource Type
ISSN
0743684X
eISSN
10988947
Scopus ID
2-s2.0-85200358028
Journal Title
Journal of Reconstructive Microsurgery
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Reconstructive Microsurgery (2024)
Suggested Citation
Voravitvet T.Y., Huang Y., Voravitvet S., Larsson J., Lien P.H., Chuang D.C.C., Lu J.C.Y., Chang T.N.J. Dynamic Eye Closure Restoration in Facial Palsy with Neurotized Platysma Muscle Graft in Rats. Journal of Reconstructive Microsurgery (2024). doi:10.1055/s-0044-1788565 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100450
Title
Dynamic Eye Closure Restoration in Facial Palsy with Neurotized Platysma Muscle Graft in Rats
Corresponding Author(s)
Other Contributor(s)
Abstract
Background One of the most devastating deficits of facial paralysis is eyelid dysfunction, which is controlled by the orbicularis oculi muscle (OOM), as it leads to loss of the protective mechanism of the eye. This study used a rat model to assess the functional outcomes of neurotized platysma muscle grafts (PMGs) for OOM replacement. Methods Forty male Sprague-Dawley rats with iatrogenic right eyelid dysfunction were divided into five groups: one control group and four groups utilizing PMG with different sources of nerve innervation. Eyelid function recovery was assessed at 2, 4, 6, and 8 weeks. The PMGs were harvested for pathological examination at the end of the study. Results All rats except those in the control group and one from the group using ipsilateral frontal and upper zygomatic frontal nerve branches directly neurotized to the PMG (nerve-to-muscle) recovered eyelid closure function within 8 weeks of the study period. The mean recovery time was 3.87 ± 1.28 weeks. A total of 87.5% of rats that had the contralateral zygomatic branch as the donor nerve regained the consensual corneal reflex (p -value < 0.001). Conclusion Replacement of neurotized PMG for OOM function is successful in a rat model. Using the upper zygomatic branch as the donor nerve, it was possible to restore the consensual corneal reflex. This method shows promise for further human studies.