Risk Factors of Renal Tubular Dysfunction in Thai People Living with HIV Receiving Tenofovir Disoproxil Fumarate
13
item.page.dc.date.issued
2022-01-01
item.page.dc.type
item.page.dc.identifier.issn
23259574
item.page.dc.identifier.eissn
23259582
item.page.dc.identifier.doi
item.page.dc.identifier.scopus
2-s2.0-85141004846
item.page.dc.identifier.pmid
36314476
item.page.oaire.citation.title
Journal of the International Association of Providers of AIDS Care
item.page.oaire.citation.volume
21
item.page.dc.rights.holder
SCOPUS
item.page.dc.identifier.citation
Journal of the International Association of Providers of AIDS Care Vol.21 (2022)
punsarn.item.page.citation
Phuphuakrat A., Pasomsub E., Chantratita W., Mahasirimongkol S., Disthabanchong S., Sungkanuparph S., Kiertiburanakul S. Risk Factors of Renal Tubular Dysfunction in Thai People Living with HIV Receiving Tenofovir Disoproxil Fumarate. Journal of the International Association of Providers of AIDS Care Vol.21 (2022). doi:10.1177/23259582221134751 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85042
item.page.dc.title
Risk Factors of Renal Tubular Dysfunction in Thai People Living with HIV Receiving Tenofovir Disoproxil Fumarate
item.page.dc.contributor.author
item.page.oairecerif.author.affiliation
item.page.dc.contributor.other
item.page.dc.description.abstract
Tenofovir disoproxil fumarate (TDF) associates with renal tubular dysfunction (RTD) in some people living with HIV (PLWH). We studied clinical and genetic factors associated with RTD in Thai PLWH receiving TDF. RTD was diagnosed in 13 of 65 (20%) patients. The median (interquartile range) age and CD4 cell counts were 43.8 (40.4-50.9) years and 554 (437-716) cells/mm3, respectively. The median duration of TDF use was 46.9 (31.5-54.1) months. Univariate logistic regression demonstrated body mass index (BMI), concomitant use of protease inhibitor (PI), hyperlipidemia, and homozygous C/C SNP rs1059751 of ABCC4 gene as predisposing factors of RTD. In multivariate model, concomitant use of PI [adjusted odds ratio (aOR) 11.39; 95% confidence interval (CI), 1.59- 81.56; P = 0.015], hyperlipidemia (aOR 8.59; 95% CI, 1.46-50.40; P = 0.017), and BMI (aOR 0.76; 95% CI, 0.59-0.98; P = 0.037) remained associated with RTD in patients receiving TDF. PLWH receiving TDF with the presence of these factors should be closely monitored for RTD.