A multivariable normal tissue complication probability model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma patients in the modern radiotherapy era
Issued Date
2024-01-19
Resource Type
eISSN
13499157
Scopus ID
2-s2.0-85183287414
Pubmed ID
37996086
Journal Title
Journal of radiation research
Volume
65
Issue
1
Start Page
119
End Page
126
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of radiation research Vol.65 No.1 (2024) , 119-126
Suggested Citation
Wongwattananard S., Prayongrat A., Srimaneekarn N., Hayter A., Sophonphan J., Kiatsupaibul S., Veerabulyarith P., Rakvongthai Y., Ritlumlert N., Kitpanit S., Kannarunimit D., Lertbutsayanukul C., Chakkabat C. A multivariable normal tissue complication probability model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma patients in the modern radiotherapy era. Journal of radiation research Vol.65 No.1 (2024) , 119-126. 126. doi:10.1093/jrr/rrad091 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/96012
Title
A multivariable normal tissue complication probability model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma patients in the modern radiotherapy era
Corresponding Author(s)
Other Contributor(s)
Abstract
Radiation-induced hypothyroidism (RHT) is a common long-term complication for nasopharyngeal carcinoma (NPC) survivors. A model using clinical and dosimetric factors for predicting risk of RHT could suggest a proper dose-volume parameters for the treatment planning in an individual level. We aim to develop a multivariable normal tissue complication probability (NTCP) model for RHT in NPC patients after intensity-modulated radiotherapy or volumetric modulated arc therapy. The model was developed using retrospective clinical data and dose-volume data of the thyroid and pituitary gland based on a standard backward stepwise multivariable logistic regression analysis and was then internally validated using 10-fold cross-validation. The final NTCP model consisted of age, pretreatment thyroid-stimulating hormone and mean thyroid dose. The model performance was good with an area under the receiver operating characteristic curve of 0.749 on an internal (200 patients) and 0.812 on an external (25 patients) validation. The mean thyroid dose at ≤45 Gy was suggested for treatment plan, owing to an RHT incidence of 2% versus 61% in the >45 Gy group.