Efficacy and Safety of House Dust Mite Sublingual Immunotherapy Tablet in Allergic Asthma: A Systematic Review of Randomized Controlled Trials
1
Issued Date
2022-05-01
Resource Type
ISSN
22132198
Scopus ID
2-s2.0-85125912929
Pubmed ID
35181547
Journal Title
Journal of Allergy and Clinical Immunology: In Practice
Volume
10
Issue
5
Start Page
1342
End Page
1355.e24
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Allergy and Clinical Immunology: In Practice Vol.10 No.5 (2022) , 1342-1355.e24
Suggested Citation
Wongsa C., Phinyo P., Sompornrattanaphan M., Krikeerati T., Lumkul L., Thongngarm T. Efficacy and Safety of House Dust Mite Sublingual Immunotherapy Tablet in Allergic Asthma: A Systematic Review of Randomized Controlled Trials. Journal of Allergy and Clinical Immunology: In Practice Vol.10 No.5 (2022) , 1342-1355.e24. 1355.e24. doi:10.1016/j.jaip.2022.01.046 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85934
Title
Efficacy and Safety of House Dust Mite Sublingual Immunotherapy Tablet in Allergic Asthma: A Systematic Review of Randomized Controlled Trials
Author's Affiliation
Other Contributor(s)
Abstract
Background: House dust mite sublingual immunotherapy (HDM SLIT) effectively treats allergic rhinitis (AR). However, the evidence of HDM SLIT for allergic asthma remained limited. Objective: To systematically review the efficacy and safety of HDM SLIT tablets in patients with allergic asthma. Methods: We performed a systematic search through PubMed, Scopus, EMBASE, Web of Science, the Cochrane Center of Controlled Trials, and Google Scholar for randomized controlled trials (RCTs) that addressed the efficacy and safety of HDM SLIT tablets compared with placebo or no intervention in allergic asthma from their inception date until September 2021. The primary outcome was the reduction in inhaled corticosteroids (ICS) dose. Additional outcomes were asthma control, exacerbation, lung function, quality-of-life, and adverse events. Results: There were 7 RCTs, 5 studies in allergic asthma (4 in adults and 1 in children), and 2 in AR with or without asthma. The 6 standardized quality (SQ) HDM effectively reduced ICS dose in well- to partly controlled mild-to-moderate asthma in 1 RCT. Two RCTs evaluated the efficacy of 6 SQ and 12 SQ HDM in reducing asthma exacerbation in partly controlled moderate-to-severe asthma, and their results were inconsistent. One study in children with mild-to-moderate asthma found no benefit of HDM SLIT. Two RCTs in AR with or without mild-to-moderate asthma showed improvement of asthma symptoms. Adverse events were primarily local, and anaphylaxis treated with epinephrine was reported in 3 patients. Conclusions: The HDM SLIT tablets tend to effectively reduce ICS use in adults and adolescents with well- to partly controlled mild-to-moderate allergic asthma with a favorable safety profile.