Prevalence of High-Risk Prostate Cancer Metastasis to Cloquet's Ilioinguinal Lymph Node
1
Issued Date
2022-06-01
Resource Type
ISSN
00219355
eISSN
15351386
Scopus ID
2-s2.0-85130000807
Pubmed ID
35050701
Journal Title
Journal of Bone and Joint Surgery
Volume
207
Issue
6
Start Page
1222
End Page
1226
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Bone and Joint Surgery Vol.207 No.6 (2022) , 1222-1226
Suggested Citation
Plata Bello A., Apatov S.E., Benfante N.E., Rivero Belenchón I., Picola Brau N., Mercader Barrull C., Jenjitranant P., Vickers A.J., Fine S.W., Touijer K.A. Prevalence of High-Risk Prostate Cancer Metastasis to Cloquet's Ilioinguinal Lymph Node. Journal of Bone and Joint Surgery Vol.207 No.6 (2022) , 1222-1226. 1226. doi:10.1097/JU.0000000000002439 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85830
Title
Prevalence of High-Risk Prostate Cancer Metastasis to Cloquet's Ilioinguinal Lymph Node
Other Contributor(s)
Abstract
Purpose:Cloquet's node, located at the junction between the deep inguinal nodes and the external iliac chain, is easily accessible and commonly excised during pelvic lymph node dissection for prostate cancer. However, we hypothesize that Cloquet's node is not part of lymphatic metastatic spread of prostate cancer.Materials and Methods:Between September 2016 and June 2019, 105 consecutive patients with high-risk prostate cancer (cT3a or Grade Group 4/5, or prostate specific antigen >20 ng/ml) underwent a laparoscopic radical prostatectomy and pelvic lymph node dissection. First, Cloquet's node was identified, retrieved and submitted separately to pathology as right and left Cloquet's node. Next, a pelvic lymph node dissection was completed including the external iliac, obturator fossa and hypogastric nodal packets. Each lymph node was cut into 3 mm slices which were separately embedded in paraffin, stained with hematoxylin and eosin, and examined microscopically.Results:The final analysis included 95 patients. In this high-risk population, the median number of nodes removed was 22 (IQR 18-29); 39/95 patients (41%) had lymph node metastasis. The median number of Cloquet's nodes removed was 2 (IQR 2-3). Cloquet's node was negative in all but 1 patient (1.1%), who had very high-risk features and high metastatic burden in the lymph nodes.Conclusions:In high-risk prostate cancer, metastasis to the ilioinguinal node of Cloquet is rare. Given this low prevalence, Cloquet's node can be safely excluded from the pelvic lymph node dissection template.