The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia
Issued Date
2022-09-01
Resource Type
ISSN
16616596
eISSN
14220067
Scopus ID
2-s2.0-85138357827
Pubmed ID
36142738
Journal Title
International Journal of Molecular Sciences
Volume
23
Issue
18
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences Vol.23 No.18 (2022)
Suggested Citation
Chaichompoo P., Svasti S., Smith D.R. The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia. International Journal of Molecular Sciences Vol.23 No.18 (2022). doi:10.3390/ijms231810811 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83621
Title
The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
β-Thalassemia is one of the most common genetically inherited disorders worldwide, and it is characterized by defective β-globin chain synthesis leading to reduced or absent β-globin chains. The excess α-globin chains are the key factor leading to the death of differentiating erythroblasts in a process termed ineffective erythropoiesis, leading to anemia and associated complications in patients. The mechanism of ineffective erythropoiesis in β-thalassemia is complex and not fully understood. Autophagy is primarily known as a cell recycling mechanism in which old or dysfunctional proteins and organelles are digested to allow recycling of constituent elements. In late stage, erythropoiesis autophagy is involved in the removal of mitochondria as part of terminal differentiation. Several studies have shown that autophagy is increased in earlier erythropoiesis in β-thalassemia erythroblasts, as compared to normal erythroblasts. This review summarizes what is known about the role of autophagy in β-thalassemia erythropoiesis and shows that modulation of autophagy and its interplay with apoptosis may provide a new therapeutic route in the treatment of β-thalassemia. Literature was searched and relevant articles were collected from databases, including PubMed, Scopus, Prospero, Clinicaltrials.gov, Google Scholar, and the Google search engine. Search terms included: β-thalassemia, ineffective erythropoiesis, autophagy, novel treatment, and drugs during the initial search. Relevant titles and abstracts were screened to choose relevant articles. Further, selected full-text articles were retrieved, and then, relevant cross-references were scanned to collect further information for the present review.