Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine Zn<sup>II</sup> complex
Issued Date
2022-09-20
Resource Type
ISSN
00032654
eISSN
13645528
Scopus ID
2-s2.0-85140488867
Pubmed ID
36172837
Journal Title
Analyst
Volume
147
Issue
21
Start Page
4910
End Page
4918
Rights Holder(s)
SCOPUS
Bibliographic Citation
Analyst Vol.147 No.21 (2022) , 4910-4918
Suggested Citation
Srinarawat W., Hemstapat R., Tawonsawatruk T., Patikarnmonthon N., Hamachi I., Ojida A., Wongkongkatep J. Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine Zn<sup>II</sup> complex. Analyst Vol.147 No.21 (2022) , 4910-4918. 4918. doi:10.1039/d2an01257j Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83604
Title
Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine Zn<sup>II</sup> complex
Other Contributor(s)
Abstract
Calcium pyrophosphate deposition disease, previously known as pseudogout, is a type of chronic and painful joint arthropathy. Accurate identification of calcium pyrophosphate dihydrate (CPPD) single crystals is crucial for determining the best course of treatment. In this study, a two-step method involving alizarin red S (ARS) and a xanthene dipicolylamine ZnII (XDZ) complex was employed for the identification of CPPD single crystals in both triclinic and monoclinic forms using a fluorescence microscope and a microplate reader. The accurate identification method proposed in this study has the potential to advance the diagnosis and treatment of patients suffering from painful gouty arthritis.