An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
Issued Date
2022-06-17
Resource Type
eISSN
22352988
Scopus ID
2-s2.0-85133302149
Pubmed ID
35782127
Journal Title
Frontiers in Cellular and Infection Microbiology
Volume
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Frontiers in Cellular and Infection Microbiology Vol.12 (2022)
Suggested Citation
Khuntayaporn P., Thirapanmethee K., Chomnawang M.T. An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli. Frontiers in Cellular and Infection Microbiology Vol.12 (2022). doi:10.3389/fcimb.2022.882236 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84970
Title
An Update of Mobile Colistin Resistance in Non-Fermentative Gram-Negative Bacilli
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Colistin, the last resort for multidrug and extensively drug-resistant bacterial infection treatment, was reintroduced after being avoided in clinical settings from the 1970s to the 1990s because of its high toxicity. Colistin is considered a crucial treatment option for Acinetobacter baumannii and Pseudomonas aeruginosa, which are listed as critical priority pathogens for new antibiotics by the World Health Organization. The resistance mechanisms of colistin are considered to be chromosomally encoded, and no horizontal transfer has been reported. Nevertheless, in November 2015, a transmissible resistance mechanism of colistin, called mobile colistin resistance (MCR), was discovered. Up to ten families with MCR and more than 100 variants of Gram-negative bacteria have been reported worldwide. Even though few have been reported from Acinetobacter spp. and Pseudomonas spp., it is important to closely monitor the epidemiology of mcr genes in these pathogens. Therefore, this review focuses on the most recent update on colistin resistance and the epidemiology of mcr genes among non-fermentative Gram-negative bacilli, especially Acinetobacter spp. and P. aeruginosa.