Clozapine Use for Bipolar Disorder: An Asian Psychotropic Prescription Patterns Consortium Study
Issued Date
2023-05-01
Resource Type
ISSN
02710749
eISSN
1533712X
Scopus ID
2-s2.0-85158894715
Pubmed ID
37068038
Journal Title
Journal of Clinical Psychopharmacology
Volume
43
Issue
3
Start Page
278
End Page
282
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Psychopharmacology Vol.43 No.3 (2023) , 278-282
Suggested Citation
Loo L.W.J., Chew Q.H., Lin S.K., Yang S.Y., Ouyang W.C., Chen C.K., Park S.C., Jang O.J., Park J.H., Chee K.Y., Ding K.S., Chong J., Zhang L., Li K., Zhu X., Jatchavala C., Pariwatcharakul P., Kallivayalil R.A., Grover S., Avasthi A., Ansari M., Maramis M.M., Aung P.P., Sartorius N., Xiang Y.T., Tan C.H., Chong M.Y., Park Y.C., Kato T.A., Shinfuku N., Baldessarini R.J., Sim K. Clozapine Use for Bipolar Disorder: An Asian Psychotropic Prescription Patterns Consortium Study. Journal of Clinical Psychopharmacology Vol.43 No.3 (2023) , 278-282. 282. doi:10.1097/JCP.0000000000001693 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82774
Title
Clozapine Use for Bipolar Disorder: An Asian Psychotropic Prescription Patterns Consortium Study
Author(s)
Loo L.W.J.
Chew Q.H.
Lin S.K.
Yang S.Y.
Ouyang W.C.
Chen C.K.
Park S.C.
Jang O.J.
Park J.H.
Chee K.Y.
Ding K.S.
Chong J.
Zhang L.
Li K.
Zhu X.
Jatchavala C.
Pariwatcharakul P.
Kallivayalil R.A.
Grover S.
Avasthi A.
Ansari M.
Maramis M.M.
Aung P.P.
Sartorius N.
Xiang Y.T.
Tan C.H.
Chong M.Y.
Park Y.C.
Kato T.A.
Shinfuku N.
Baldessarini R.J.
Sim K.
Chew Q.H.
Lin S.K.
Yang S.Y.
Ouyang W.C.
Chen C.K.
Park S.C.
Jang O.J.
Park J.H.
Chee K.Y.
Ding K.S.
Chong J.
Zhang L.
Li K.
Zhu X.
Jatchavala C.
Pariwatcharakul P.
Kallivayalil R.A.
Grover S.
Avasthi A.
Ansari M.
Maramis M.M.
Aung P.P.
Sartorius N.
Xiang Y.T.
Tan C.H.
Chong M.Y.
Park Y.C.
Kato T.A.
Shinfuku N.
Baldessarini R.J.
Sim K.
Author's Affiliation
Faculty of Health Sciences
Siriraj Hospital
Graduate School of Medical Sciences
The Affiliated Guangji Hospital of Soochow University
Lee Kong Chian School of Medicine
Jeju National University Hospital
Beijing Anding Hospital, Capital Medical University
Hanyang University Guri Hospital
Inje University Paik Hospital
University of Yangon
Universitas Airlangga
Liaquat University of Medical and Health Sciences
Chang Gung Memorial Hospital
Hanyang University College of Medicine
Taipei City Hospital Taiwan
Kuala Lumpur Hospital
Faculty of Medicine, Prince of Songkia University
University of Macau
Seinan Gakuin University
National University of Singapore
McLean Hospital
Kementerian Kesihatan Malaysia
College of Medicine
Singapore Institute of Mental Health
Harvard Medical School
Postgraduate Institute of Medical Education & Research, Chandigarh
Ministry of Health and Welfare
Pushpagiri Institute of Medical Sciences
Hebei Mental Health Centre
Linkou Chang Gung Memorial Hospital
Association for the Improvement of Mental Health Programs
Regency Specialist Hospital
Hospital Bahagia Ulu Kinta
Shu-Zen Junior College of Medicine and Management
Siriraj Hospital
Graduate School of Medical Sciences
The Affiliated Guangji Hospital of Soochow University
Lee Kong Chian School of Medicine
Jeju National University Hospital
Beijing Anding Hospital, Capital Medical University
Hanyang University Guri Hospital
Inje University Paik Hospital
University of Yangon
Universitas Airlangga
Liaquat University of Medical and Health Sciences
Chang Gung Memorial Hospital
Hanyang University College of Medicine
Taipei City Hospital Taiwan
Kuala Lumpur Hospital
Faculty of Medicine, Prince of Songkia University
University of Macau
Seinan Gakuin University
National University of Singapore
McLean Hospital
Kementerian Kesihatan Malaysia
College of Medicine
Singapore Institute of Mental Health
Harvard Medical School
Postgraduate Institute of Medical Education & Research, Chandigarh
Ministry of Health and Welfare
Pushpagiri Institute of Medical Sciences
Hebei Mental Health Centre
Linkou Chang Gung Memorial Hospital
Association for the Improvement of Mental Health Programs
Regency Specialist Hospital
Hospital Bahagia Ulu Kinta
Shu-Zen Junior College of Medicine and Management
Other Contributor(s)
Abstract
Background Pharmacoepidemiological studies of clozapine use to treat bipolar disorder (BD), especially in Asia, are rare, although they can provide insights into associated clinical characteristics and support international comparisons of indications and drug dosing. Methods We examined the prevalence and clinical correlates of clozapine treatment for BD in 13 Asian countries and regions (China, Hong Kong SAR, India, Indonesia, Japan, Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, and Thailand) within an Asian Prescription Patterns Research Consortium. We compared BD patients treated with clozapine or not in initial bivariate comparisons followed by multivariable logistic regression modeling. Results Clozapine was given to 2.13% of BD patients overall, at a mean daily dose of 275 (confidence interval, 267-282) chlorpromazine-equivalent mg/day. Patients receiving clozapine were older, more likely males, hospitalized, currently manic, and given greater numbers of mood-stabilizing and antipsychotic drugs in addition to clozapine. Logistic regression revealed that older age, male sex, current mania, and greater number of other antipsychotics remained significantly associated with clozapine treatment. Clozapine use was not associated with depressed mood, remission of illness, suicidal risk, or electroconvulsive treatment within the previous 12 months. Conclusions The identified associations of clozapine use with particular clinical features call for vigilance in personalized clinical monitoring so as to optimize clinical outcomes of BD patients and to limit risks of adverse effects of polytherapy.