Left Atrial Diameter in the Prediction of Thromboembolic Event and Death in Atrial Fibrillation
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Issued Date
2022-04-01
Resource Type
eISSN
20770383
Scopus ID
2-s2.0-85127081492
Journal Title
Journal of Clinical Medicine
Volume
11
Issue
7
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Medicine Vol.11 No.7 (2022)
Suggested Citation
Krittayaphong R., Winijkul A., Sairat P. Left Atrial Diameter in the Prediction of Thromboembolic Event and Death in Atrial Fibrillation. Journal of Clinical Medicine Vol.11 No.7 (2022). doi:10.3390/jcm11071838 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/87339
Title
Left Atrial Diameter in the Prediction of Thromboembolic Event and Death in Atrial Fibrillation
Author(s)
Author's Affiliation
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Abstract
Background: This study aimed to determine the predictive value of left atrial diameter (LAD), and the incremental prognostic value of LAD in combination with CHA2DS2-VASc score for predicting thromboembolic event and all-cause death in patients with non-valvular atrial fibrillation (AF). Methods: This is a prospective study from 27 hospitals during 2014–2017. LADi is LAD data indexed by body surface area, and LADi in the 4th quartile (LADi Q4) was considered high. Results: A total of 2251 patients (mean age 67.4 years, 58.6% male) were enrolled. Mean follow-up duration was 32.3 months. Rates of thromboembolic events and all-cause death were significantly higher in LADi Q4 patients than in LADi Q1–3 patients (2.89 vs. 1.11 per 100 person-years, p < 0.001, and 7.52 vs. 3.13 per 100 person-years, p < 0.001, respectively). LADi Q4 is an independent predictor of thromboembolic events and all-cause death with an adjusted hazard ratio and 95% confidence interval of 1.94 (1.24–3.05) and 1.81 (1.38–2.37), respectively. LADi has incremental prognostic value on top of the CHA2DS2-VASc score with the increase in global chi-square for thromboembolism (p = 0.005) and all-cause death (p < 0.001). Conclusions: LADi is an independent predictor of thromboembolic event and has incremental prognostic value in combination with CHA2DS2-VASc score in AF patients.