Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
Issued Date
2023-12-01
Resource Type
eISSN
17498546
Scopus ID
2-s2.0-85178231801
Journal Title
Chinese Medicine (United Kingdom)
Volume
18
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Chinese Medicine (United Kingdom) Vol.18 No.1 (2023)
Suggested Citation
Faysal M., Khan J., Zehravi M., Nath N., Singh L.P., Kakkar S., Perusomula R., Khan P.A., Nainu F., Asiri M., Khan S.L., Das R., Emran T.B., Wilairatana P. Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint. Chinese Medicine (United Kingdom) Vol.18 No.1 (2023). doi:10.1186/s13020-023-00846-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91415
Title
Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
Author's Affiliation
Buraydah Private Colleges
Faculty of Tropical Medicine, Mahidol University
Vishnu Institute of Pharmaceutical Education and Research
International Islamic University Chittagong
Hasanuddin University
King Khalid University
Daffodil International University
University of Dhaka
The Warren Alpert Medical School
Maharshi Dayanand University
N.B.S. Institute of Pharmacy
Gopal Narayan Singh University
Anwarul Uloom College of Pharmacy
Faculty of Tropical Medicine, Mahidol University
Vishnu Institute of Pharmaceutical Education and Research
International Islamic University Chittagong
Hasanuddin University
King Khalid University
Daffodil International University
University of Dhaka
The Warren Alpert Medical School
Maharshi Dayanand University
N.B.S. Institute of Pharmacy
Gopal Narayan Singh University
Anwarul Uloom College of Pharmacy
Other Contributor(s)
Abstract
Honokiol is a neolignan biphenol found in aerial parts of the Magnolia plant species. The Magnolia plant species traditionally belong to China and have been used for centuries to treat many pathological conditions. Honokiol mitigates the severity of several pathological conditions and has the potential to work as an anti-inflammatory, anti-angiogenic, anticancer, antioxidant, and neurotherapeutic agent. It has a long history of being employed in the healthcare practices of Southeast Asia, but in recent years, a greater scope of research has been conducted on it. Plenty of experimental evidence suggests it could be beneficial as a neuroprotective bioactive molecule. Honokiol has several pharmacological effects, leading to its exploration as a potential therapy for neurological diseases (NDs), including Alzheimer's disease (AD), Parkinson’s disease (PD), cerebral ischemia, anxiety, depression, spinal cord injury, and so on. So, based on the previous experimentation reports, our goal is to discuss the neuroprotective properties of honokiol. Besides, honokiol derivatives have been highlighted recently as possible therapeutic options for NDs. So, this review focuses on honokiol's neurotherapeutic actions and toxicological profile to determine their safety and potential use in neurotherapeutics.