Menopausal hormonal therapy in surgically menopausal women with underlying endometriosis
Issued Date
2022-01-01
Resource Type
ISSN
13697137
eISSN
14730804
Scopus ID
2-s2.0-85119370094
Pubmed ID
34783284
Journal Title
Climacteric
Volume
25
Issue
4
Start Page
388
End Page
394
Rights Holder(s)
SCOPUS
Bibliographic Citation
Climacteric Vol.25 No.4 (2022) , 388-394
Suggested Citation
Tanmahasamut P. Menopausal hormonal therapy in surgically menopausal women with underlying endometriosis. Climacteric Vol.25 No.4 (2022) , 388-394. 394. doi:10.1080/13697137.2021.1998434 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86733
Title
Menopausal hormonal therapy in surgically menopausal women with underlying endometriosis
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objective: This study aimed to investigate the relationship between menopausal hormone therapy (MHT) and endometriosis recurrence in women who underwent hysterectomy with bilateral salpingo-oophorectomy to treat endometriosis. Method: This retrospective cohort study included 330 women who underwent definitive surgery to treat endometriosis during 1996–2012. Follow-up data until December 2018 were analyzed. Patients were grouped as MHT non-users (non-MHT, n = 43), estrogen-only therapy (ET, n = 230), estrogen–progestogen therapy (EPT, n = 39) and tibolone (n = 18). Results: The mean age at surgery was 41.5 ± 5.3 years. The overall median follow-up duration was 6.0 years (interquartile range [IQR]: 3.0–10.4), and the median duration of MHT use was 66.0 months (IQR: 36.0–116.3). The overall recurrence rate was 3.0% (95% confidence interval: 1.5–5.5) and there was no significant difference in recurrence among the study groups. Disease recurrence resolved after MHT discontinuation, or change in MHT type and/or dose. Conclusions: No significant association between MHT use and endometriosis recurrence was found in this study. The endometriosis recurrence rate was non-significantly different between ET and EPT. Recurrent endometriosis can be successfully treated without invasive measures. No study patients had malignant transformation after a median follow-up of 6 years. Our findings suggest that any of the three evaluated MHT regimens can be used in surgically menopausal Thai women with underlying endometriosis.