Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma
Issued Date
2024-01-01
Resource Type
ISSN
20499434
eISSN
20499442
Scopus ID
2-s2.0-85178955668
Journal Title
Biomedical Reports
Volume
20
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomedical Reports Vol.20 No.1 (2024)
Suggested Citation
Thanasan S., Ruangritchankul K., Kitkumthorn N., Keelawat S., Mahattanasakul P. Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma. Biomedical Reports Vol.20 No.1 (2024). doi:10.3892/br.2023.1702 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91443
Title
Protein expression analysis for predicting recurrent laryngeal squamous cell carcinoma
Other Contributor(s)
Abstract
The expression of a number of proteins plays a major role in predicting recurrent laryngeal squamous cell carcinoma (LSCC). Thus, the aim of the present study was to investigate the expression of 16 selected proteins as prognostic indicators for recurrent and non-recurrent LSCC. Samples from a total of 41 patients with LSCC were investigated by immunohisto-chemistry. Digital image analysis was performed, and various associated factors were calculated. Histoscore (H-score) and receiver operating characteristic curves were used to divide protein expression in high and low for predicting disease recurrence. Disease-free survival (DFS) curves, crude hazard ratios (HRs) and adjusted HRs were analyzed and compared. Significantly different H-scores were found between the recurrent and non-recurrent groups in terms of pRb and c-Met expression. pRb was expressed at high levels in recurrent LSCC, while c-Met was expressed at low levels. Patients with low pRb expression had a longer DFS than those with high pRb expression (log-rank χ2, 5.161; P=0.023). Patients with high c-Met expression had a longer DFS than those with low c-Met expression (log-rank χ2, 6.441; P=0.011). Moreover, patients with high pRb expression and low c-Met expression had the shortest DFS (log-rank χ2, 11.827; P=0.008). Differentiated histological factors had an impact on the risk of recurrence (Cox regression test; crude HR, 9.53; 95% confidence interval, 1.214-74.819; P=0.032). The present study demonstrated that the grading of differentiated squamous cell carcinoma, pRb and c-Met expression are the most useful prognostic factors for the prediction of recurrent LSCC. These might be further applied as potential markers for clinical use.