Antiinflammatory and antipruritic effects of Solanum trilobatum L. fruit extracts
3
Issued Date
2006
Copyright Date
2006
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xiii, 123 leaves : ill.
ISBN
9740469272
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Biopharmaceutical Sciences))--Mahidol University, 2006
Suggested Citation
Wanthanee Hanchang Antiinflammatory and antipruritic effects of Solanum trilobatum L. fruit extracts. Thesis (M.Sc. (Biopharmaceutical Sciences))--Mahidol University, 2006. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/106305
Title
Antiinflammatory and antipruritic effects of Solanum trilobatum L. fruit extracts
Alternative Title(s)
ฤทธิ์ต้านการอักเสบและต้านอาการคันของสารสกัดจากผลมะแว้งเครือ
Author(s)
Advisor(s)
Abstract
The fruits of Solanum trilobatum L. (Thai name: mawaeng krueo), a shrub of the family Solanaceae, were extracted with water (aqueous extract), 95% ethanol (ethanolic extract) and 95% ethanol: HCl (10:1) (partially purified extract). The extracts were tested for anti-inflammatory activity in mice using a topical model and peritoneal inflammatory models. The ethanolic extract was also tested for antipruritic activity. Thetopical model was designed to evaluate the effectiveness of the extracts for both preventive and curative activity against ethyl- phenylpropiolate (EPP)-induced ear edema. All substances were applied topically on the inner and outer surface of a mouse's ear. Pretreatment with either one of the three ex tracts mentioned above (0.5, 1 and 2 mg/ear) two hours before EPP application prevented ear ed ema in a dose-dependent manner. The ear edema was also significantly suppressed in a dose dependent manner (P<0.01) when the extract (0.5, 1 and 2 mg/ear for the aqueous and the ethanolic extract and 0.25, 0.5 and 1 mg/ear for the partially purified extract) was a pplied one hour after EPP application. Both the preventive and curative effects of the extracts lasted throughout the observation period (four hours) and were comparable to the results obtai ned with the reference antiinflammatory drug (dexamethasone, 0.05 mg/ear). Two peritoneal inflammatory mode ls, i.e. acetic acid-induced vascular permeability and carrageenan-induced leukocyte migration, we re selected for the testing of internal antiinflammatory activity of the extracts. Oral ad ministration of the etha nolic extract (200, 400 and 600 mg/kg) significantly exhibited an antiinfl ammatory effect (P<0.001) in both models. However, the extract at all the doses tested was less potent than the two reference antiinflammatory drugs (dexamethasone, 1 mg/kg and indomethacin, 10
Description
Biopharmaceutical Sciences (Mahidol University 2006)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Pharmacy
Degree Discipline
Biopharmaceutical Sciences
Degree Grantor(s)
Mahidol University