Duration of bite force reduction following a single injection of botulinum toxin in the masseter muscle bilaterally: A one-year non-randomized trial
Issued Date
2023-05-01
Resource Type
ISSN
0305182X
eISSN
13652842
Scopus ID
2-s2.0-85149383221
Journal Title
Journal of Oral Rehabilitation
Volume
50
Issue
5
Start Page
343
End Page
350
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Oral Rehabilitation Vol.50 No.5 (2023) , 343-350
Suggested Citation
Ågren M., Nanchaipruek Y., Phumariyapong P., Apinuntham C., Rakchart S., Pettersson M., Wanitphakdeedecha R. Duration of bite force reduction following a single injection of botulinum toxin in the masseter muscle bilaterally: A one-year non-randomized trial. Journal of Oral Rehabilitation Vol.50 No.5 (2023) , 343-350. 350. doi:10.1111/joor.13434 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81545
Title
Duration of bite force reduction following a single injection of botulinum toxin in the masseter muscle bilaterally: A one-year non-randomized trial
Other Contributor(s)
Abstract
Background: Previous studies concerning the effect of botulinum toxin in masseter muscle have mainly reported effects observed through inspection of facial features or differences in pain levels. One systematic review of studies utilizing objective measurements reported that long-term muscular effect of botulinum neurotoxin injections into masseter muscle was inconclusive. Objective: To evaluate the duration of reduced maximal voluntary bite force (MVBF) after botulinum toxin intervention. Methods: The intervention group was comprised of individuals seeking aesthetic treatment for masseter reduction (n = 20), the reference group (n = 12) comprised of individuals with no intervention. Intervention through 25 units of Xeomin® (Merz Pharma GmbH & Co KGaA, Frankfurt am Main, Germany) botulinum neurotoxin type A injected into the masseter muscles bilaterally (totalling 50 units). A reference group did not receive any intervention. MVBF was measured in Newtons using a strain gauge meter at the incisors and first molars. MVBF was measured at baseline, at 4 weeks, 3 months, 6 months, and after 1 year. Results: Both groups were similar in terms of bite force, sex and age at baseline. MVBF remained similar compared to baseline in the reference group. At 3 months, a significant reduction at all measurement points was observed in the intervention group; at 6 months, this reduction was no longer significant. Conclusion: A single intervention of 50 units of botulinum neurotoxin results in a reversible MVBF reduction of at least 3 months, although a visually discernable reduction may be more long-lasting.