Folate and vitamin B12 deficiencies in relation to cardiovascular disease in elderly thais
Issued Date
2014
Resource Type
Language
eng
Rights
Mahidol University
Suggested Citation
Chirawat Paratthakonkun, จิราวัฒน์ ปรัตถกรกุล, Sarunya Kaewprasert, Rungsunn Tungtrongchitr, รังสรรค์ ตั้งตรงจิตร, Ngamphol Soonthornworasiri, Pattaneeya Prangthip, พัฒนียา ปรางทิพย์, Amornrat Aroonnual, อมรรัตน์ อรุณนวล, Chaowanee Chupeerach, Dumrongkiet Arthan, ดำรงเกียรติ อาจหาญ (2014). Folate and vitamin B12 deficiencies in relation to cardiovascular disease in elderly thais. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/63342
Title
Folate and vitamin B12 deficiencies in relation to cardiovascular disease in elderly thais
Abstract
Thailand’s aging population is leading to the increased prevalence of
chronic diseases, especially cardiovascular disease (CVD). However,
there have been few update reports on folate and vitamin B12 deficiencies
associated with homocysteine (Hcy). Elevated total homocysteine is an important
risk factor for CVD. This study aimed to investigate the association of folate, vitamin
B12 and CVD in elderly Thai people (over 60 years old). Two-hundred elderly Thais,
consisting of 43 male (21.5%) and 157 female (78.5%) subjects participated this study.
Serum Hcy, folate, and vitamin B12 levels were determined. High levels of Hcy were
found, (Median (Min-Max) = 11.49 (6.63-30.11) μmol/L, cutoff point ≤ 10 μmol/L).
However, folate (Median (Min-Max) = 7.20 (1.60-337) ng/mL, cutoff point < 3 ng/mL)
and vitamin B12 (Median (Min-Max) = 496.00 (37.30-4,405.00) pg/dL, cutoff point <
200 pg/dL) were within normal values. A significant negative correlation (r) between
Hcy and folate (r = -0.154, p-value = 0.033) was evident, but not seen in Hcy and
vitamin B12 (r = 0.016, p-value = 0.828). Significantly different levels of Hcy (p-value =
0.003) and folate (p-value = 0.049) were also observed among different age groups
(<65 years, 66-75 years, and >75 years). Additionally, males’ CVD risk was four-times
higher females, because of lower serum folate levels (OR = 4.30, 95%CI = 1.03-17.93,
p-value = 0.031). These results indicate a relationship between CVD, Hcy and folate,
but not vitamin B12, among elderly Thais. These findings will be useful for further
prevention policies for CVD in elderly Thais.
Description
Joint International Tropical Medicine Meeting 2014: 3D perspectives on tropical medicine: drivers, diversity and determination the 8th seminar on food-and water-borne parasitic zoonoses: 2-4 December 2014: Centara Grand Bangkok Convention Center at Central World, Bangkok, Thailand. Bangkok: Faculty of Tropical Medicine, Mahidol University; 2014. p. 262.