Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation: Ex-vivo
Issued Date
2023-08-01
Resource Type
ISSN
22135979
Scopus ID
2-s2.0-85166960294
Journal Title
Photoacoustics
Volume
32
Rights Holder(s)
SCOPUS
Bibliographic Citation
Photoacoustics Vol.32 (2023)
Suggested Citation
Manwar R., Kratkiewicz K., Mahmoodkalayeh S., Hariri A., Papadelis C., Hansen A., Pillers D.A.M., Gelovani J., Avanaki K. Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation: Ex-vivo. Photoacoustics Vol.32 (2023). doi:10.1016/j.pacs.2023.100538 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/88345
Title
Development and characterization of transfontanelle photoacoustic imaging system for detection of intracranial hemorrhages and measurement of brain oxygenation: Ex-vivo
Author's Affiliation
Siriraj Hospital
Department of NanoEngineering
College of Medicine and Health Sciences United Arab Emirates University
Barbara Ann Karmanos Cancer Institute
Shahid Beheshti University
University of Illinois at Chicago
Wayne State University School of Medicine
The University of Texas at Arlington
Harvard Medical School
Cook Children's Health Care System
Department of NanoEngineering
College of Medicine and Health Sciences United Arab Emirates University
Barbara Ann Karmanos Cancer Institute
Shahid Beheshti University
University of Illinois at Chicago
Wayne State University School of Medicine
The University of Texas at Arlington
Harvard Medical School
Cook Children's Health Care System
Other Contributor(s)
Abstract
We have developed and optimized an imaging system to study and improve the detection of brain hemorrhage and to quantify oxygenation. Since this system is intended to be used for brain imaging in neonates through the skull opening, i.e., fontanelle, we called it, Transfontanelle Photoacoustic Imaging (TFPAI) system. The system is optimized in terms of optical and acoustic designs, thermal safety, and mechanical stability. The lower limit of quantification of TFPAI to detect the location of hemorrhage and its size is evaluated using in-vitro and ex-vivo experiments. The capability of TFPAI in measuring the tissue oxygenation and detection of vasogenic edema due to brain blood barrier disruption are demonstrated. The results obtained from our experimental evaluations strongly suggest the potential utility of TFPAI, as a portable imaging modality in the neonatal intensive care unit. Confirmation of these findings in-vivo could facilitate the translation of this promising technology to the clinic.