Pharmacoepidemiologic Trends and Factors Associated With Use and Dosing of Newer Antidepressants in 8357 Patients Across Asia: A Two-Decade Perspective
Issued Date
2026-03-01
Resource Type
ISSN
17585864
eISSN
17585872
Scopus ID
2-s2.0-105033134697
Journal Title
Asia Pacific Psychiatry
Volume
18
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asia Pacific Psychiatry Vol.18 No.1 (2026)
Suggested Citation
Ying J., Chew Q.H., Si T.M., Kallivayalil R.A., Tanra A.J., Nadoushan A.H.J., Chee K.Y., Javed A., Pariwatcharakul P., Park S.C., Lin S.K., Huang K.L., Inada T., Grover S., Xiang Y.T., Sartorius N., Shinfuku N., Kato T.A., Baldessarini R.J., Sim K. Pharmacoepidemiologic Trends and Factors Associated With Use and Dosing of Newer Antidepressants in 8357 Patients Across Asia: A Two-Decade Perspective. Asia Pacific Psychiatry Vol.18 No.1 (2026). doi:10.1111/appy.70017 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115878
Title
Pharmacoepidemiologic Trends and Factors Associated With Use and Dosing of Newer Antidepressants in 8357 Patients Across Asia: A Two-Decade Perspective
Author's Affiliation
Harvard Medical School
Chang Gung Memorial Hospital
Postgraduate Institute of Medical Education and Research, Chandigarh
University of Macau
NUS Yong Loo Lin School of Medicine
Nagoya University Graduate School of Medicine
Hasanuddin University
Siriraj Hospital
Graduate School of Medicine
McLean Hospital
Lee Kong Chian School of Medicine
Kuala Lumpur Hospital
Faculty of Health Sciences
Peking University Sixth Hospital
Hanyang University Guri Hospital
Singapore Institute of Mental Health
Pushpagiri Institute of Medical Sciences and Research Centre
Seinan Gakuin University
IUMS Mental Health Research Center
Pakistan Psychiatric Research Centre
Ministry of Health and Welfare
Association for the Improvement of Mental Health Programs
Chang Gung Memorial Hospital
Postgraduate Institute of Medical Education and Research, Chandigarh
University of Macau
NUS Yong Loo Lin School of Medicine
Nagoya University Graduate School of Medicine
Hasanuddin University
Siriraj Hospital
Graduate School of Medicine
McLean Hospital
Lee Kong Chian School of Medicine
Kuala Lumpur Hospital
Faculty of Health Sciences
Peking University Sixth Hospital
Hanyang University Guri Hospital
Singapore Institute of Mental Health
Pushpagiri Institute of Medical Sciences and Research Centre
Seinan Gakuin University
IUMS Mental Health Research Center
Pakistan Psychiatric Research Centre
Ministry of Health and Welfare
Association for the Improvement of Mental Health Programs
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction: Previous studies of antidepressant prescribing patterns largely were limited to a single location or time, and very few involved Asia. This Asian Psychotropic Prescription Patterns Consortium study investigated pharmacoepidemiologic trends and factors associated with use and dosing of newer antidepressants across 12 Asian sites in 2003, 2013, and 2023. Methods: Data from each site included demographic, treatment setting, clinical features, and type and dosage of antidepressants prescribed. Sociodemographic and clinical variables were examined using univariate methods, followed by multivariable logistic and linear modeling. Results: Of 8357 adult participants (59.8% female), 82.8% received at least one modern antidepressant. Use of these drugs was strongly associated with more recent year, younger age, inpatient status, and affective or anxiety-related disorders. Higher daily antidepressant doses were associated with inpatient status, male gender, more recent year, and younger age. Discussion: This large, multisite study provides a two-decade overview of evolving antidepressant-prescribing patterns in 12 Asian sites and highlights patient characteristics associated with prescription of newer antidepressants and their dosage. Needed are further studies of psychotropic prescribing practices related to specific illness subtypes and their impact on psychosocial functioning over time among Asian patients.