Oxygen Consumption with High-Flow Nasal Oxygen versus Mechanical Ventilation- An International Multicenter Observational Study in COVID-19 Patients (PROXY-COVID)
Issued Date
2023-05-03
Resource Type
eISSN
14761645
Scopus ID
2-s2.0-85152577540
Pubmed ID
36972693
Journal Title
The American journal of tropical medicine and hygiene
Volume
108
Issue
5
Start Page
1035
End Page
1041
Rights Holder(s)
SCOPUS
Bibliographic Citation
The American journal of tropical medicine and hygiene Vol.108 No.5 (2023) , 1035-1041
Suggested Citation
Botta M., Caritg O., van Meenen D.M.P., Pacheco A., Tsonas A.M., Mooij W.E., Burgener A., Hehl T.M., Shrestha G.S., Horn J., Tuinman P.R., Paulus F., Roca O., Schultz M.J. Oxygen Consumption with High-Flow Nasal Oxygen versus Mechanical Ventilation- An International Multicenter Observational Study in COVID-19 Patients (PROXY-COVID). The American journal of tropical medicine and hygiene Vol.108 No.5 (2023) , 1035-1041. 1041. doi:10.4269/ajtmh.22-0793 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82860
Title
Oxygen Consumption with High-Flow Nasal Oxygen versus Mechanical Ventilation- An International Multicenter Observational Study in COVID-19 Patients (PROXY-COVID)
Author's Affiliation
Mahidol Oxford Tropical Medicine Research Unit
Hogeschool van Amsterdam, University of Applied Sciences
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Tribhuvan University Teaching Hospital
Universitat Autònoma de Barcelona
Hospital Universitari Vall d'Hebron
Nuffield Department of Medicine
Amsterdam UMC - University of Amsterdam
Amsterdam UMC
Hospital Parc Taulí
Hogeschool van Amsterdam, University of Applied Sciences
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
Tribhuvan University Teaching Hospital
Universitat Autònoma de Barcelona
Hospital Universitari Vall d'Hebron
Nuffield Department of Medicine
Amsterdam UMC - University of Amsterdam
Amsterdam UMC
Hospital Parc Taulí
Other Contributor(s)
Abstract
The COVID-19 pandemic led to local oxygen shortages worldwide. To gain a better understanding of oxygen consumption with different respiratory supportive therapies, we conducted an international multicenter observational study to determine the precise amount of oxygen consumption with high-flow nasal oxygen (HFNO) and with mechanical ventilation. A retrospective observational study was conducted in three intensive care units (ICUs) in the Netherlands and Spain. Patients were classified as HFNO patients or ventilated patients, according to the mode of oxygen supplementation with which a patient started. The primary endpoint was actual oxygen consumption; secondary endpoints were hourly and total oxygen consumption during the first two full calendar days. Of 275 patients, 147 started with HFNO and 128 with mechanical ventilation. Actual oxygen use was 4.9-fold higher in patients who started with HFNO than in patients who started with ventilation (median 14.2 [8.4-18.4] versus 2.9 [1.8-4.1] L/minute; mean difference = 11.3 [95% CI 11.0-11.6] L/minute; P < 0.01). Hourly and total oxygen consumption were 4.8-fold (P < 0.01) and 4.8-fold (P < 0.01) higher. Actual oxygen consumption, hourly oxygen consumption, and total oxygen consumption are substantially higher in patients that start with HFNO compared with patients that start with mechanical ventilation. This information may help hospitals and ICUs predicting oxygen needs during high-demand periods and could guide decisions regarding the source of distribution of medical oxygen.