The Use of Azelastine Hydrochloride/Fluticasone Propionate in the Management of Allergic Rhinitis in Asia: A Review
Issued Date
2024-01-01
Resource Type
eISSN
11786965
Scopus ID
2-s2.0-85199872201
Journal Title
Journal of Asthma and Allergy
Volume
17
Start Page
667
End Page
679
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Asthma and Allergy Vol.17 (2024) , 667-679
Suggested Citation
Tantilipikorn P., Kirtsreesakul V., Bunnag C., Vangveeravong M., Thanaviratananich S., Chusakul S. The Use of Azelastine Hydrochloride/Fluticasone Propionate in the Management of Allergic Rhinitis in Asia: A Review. Journal of Asthma and Allergy Vol.17 (2024) , 667-679. 679. doi:10.2147/jaa.s451733 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100218
Title
The Use of Azelastine Hydrochloride/Fluticasone Propionate in the Management of Allergic Rhinitis in Asia: A Review
Corresponding Author(s)
Other Contributor(s)
Abstract
The incidence of allergic rhinitis (AR) in Asia and the world is steadily rising. Patients experience incomplete symptom relief despite existing treatment options, which warrants the need for new therapeutic regimes. Azelastine hydrochloride/fluticasone propionate (MP-AzeFlu), a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate has been indicated in the treatment of AR. The current review discusses the effects of MP-AzeFlu versus conventional therapies in achieving superior clinical improvement with a very rapid onset of action (5 minutes). The superiority of MP-AzeFlu in offering complete symptom control with sustained relief in patients with AR compared to the existing therapeutic options is also discussed. MP-AzeFlu has been shown to improve the quality of life for patients with AR, thereby enhancing patient adherence to therapy and establishing its preference for the treatment of AR. Currently, the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines recommend the use of a combination of intranasal corticosteroids and intranasal antihistamines as first-line treatment in patients with persistent AR with visual analog scores ≥5 or when prior treatment with single agents has been ineffective. Widely published data on the efficacy and safety of its prolonged use in adults and children have validated that effective treatment of AR can be achieved with MP-AzeFlu.