Pathogenesis of Cluster 1 Duck Tembusu Virus in Ducks Reveals the Impact of Viral Genotype on Pathogenicity and Disease Severity
5
Issued Date
2023-01-01
Resource Type
ISSN
18651674
eISSN
18651682
Scopus ID
2-s2.0-105002256001
Journal Title
Transboundary and Emerging Diseases
Volume
2023
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transboundary and Emerging Diseases Vol.2023 No.1 (2023)
Suggested Citation
Tunterak W., Rungprasert K., Wannaratana S., Yurayart N., Prakairungnamthip D., Ninvilai P., Limcharoen B., Nedumpun T., Hamel R., Banlunara W., Thontiravong A. Pathogenesis of Cluster 1 Duck Tembusu Virus in Ducks Reveals the Impact of Viral Genotype on Pathogenicity and Disease Severity. Transboundary and Emerging Diseases Vol.2023 No.1 (2023). doi:10.1155/2023/9239953 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/109537
Title
Pathogenesis of Cluster 1 Duck Tembusu Virus in Ducks Reveals the Impact of Viral Genotype on Pathogenicity and Disease Severity
Corresponding Author(s)
Other Contributor(s)
Abstract
Duck Tembusu virus (DTMUV), an emerging avian pathogenic flavivirus, causes severe neurological disorders and acute egg drop syndrome in ducks. Currently, several clusters of DTMUV, including clusters 1, 2, and 3, have been identified and caused outbreaks in Asia. However, most of the DTMUV pathogenesis evaluation has mainly focused on cluster 2, while limited information is available on the pathogenesis of other DTMUV clusters, particularly cluster 1. In this study, the pathogenesis of a cluster 1 DTMUV was investigated in Cherry Valley ducks and compared to our previously reported cluster 2.1 DTMUV. Our results demonstrated that cluster 1 DTMUV was generally less pathogenic than cluster 2.1 DTMUV in ducks as evidenced by slower body weight loss, lower morbidity and mortality rates, and milder pathological changes. Concordantly, delayed viremia, reduced viral loads in blood and tissues, and shorter shedding period with lower viral loads were also observed in cluster 1 DTMUV inoculated ducks compared with those reported in cluster 2.1 DTMUV. In addition, we also found that cluster 1 DTMUV exhibited significant antigenic difference compared to cluster 2.1 DTMUV. Altogether, our findings suggest distinct pathogenicity and antigenicity between cluster 1 and 2.1 DTMUVs in ducks, highlighting the potential association between DTMUV genotype and pathogenicity/disease severity. This study enhances our understanding of DTMUV pathogenesis in ducks and provides useful information for the design and development of effective DTMUV vaccines.