Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis
Issued Date
2023-05-24
Resource Type
eISSN
15376591
Scopus ID
2-s2.0-85160206801
Pubmed ID
36750934
Journal Title
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume
76
Issue
10
Start Page
1738
End Page
1749
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Vol.76 No.10 (2023) , 1738-1749
Suggested Citation
Phongkhun K., Pothikamjorn T., Srisurapanont K., Manothummetha K., Sanguankeo A., Thongkam A., Chuleerarux N., Leksuwankun S., Meejun T., Thanakitcharu J., Walker M., Gopinath S., Torvorapanit P., Langsiri N., Worasilchai N., Moonla C., Plongla R., Kates O.S., Nematollahi S., Permpalung N. Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Vol.76 No.10 (2023) , 1738-1749. 1749. doi:10.1093/cid/ciad064 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82951
Title
Prevalence of Ocular Candidiasis and Candida Endophthalmitis in Patients With Candidemia: A Systematic Review and Meta-Analysis
Author's Affiliation
Siriraj Hospital
Faculty of Medicine, Chiang Mai University
Chulalongkorn University
King Chulalongkorn Memorial Hospital
University of Arizona College of Medicine – Tucson
National Institutes of Health (NIH)
Faculty of Medicine, Srinakharinwirot University
Jackson Memorial Hospital
Faculty of Medicine, Chulalongkorn University
Johns Hopkins School of Medicine
Faculty of Medicine, Chiang Mai University
Chulalongkorn University
King Chulalongkorn Memorial Hospital
University of Arizona College of Medicine – Tucson
National Institutes of Health (NIH)
Faculty of Medicine, Srinakharinwirot University
Jackson Memorial Hospital
Faculty of Medicine, Chulalongkorn University
Johns Hopkins School of Medicine
Other Contributor(s)
Abstract
BACKGROUND: Infectious diseases and ophthalmology professional societies have disagreed regarding ocular screening in patients with candidemia. We aimed to summarize the current evidence on the prevalence of ocular candidiasis (OC) and Candida endophthalmitis (CE) according to the standardized definitions. METHODS: A literature search was conducted from the inception date through 16 October 2022 using PubMed, Embase, and SCOPUS. Pooled prevalence of ocular complications was derived from generalized linear mixed models (PROSPERO CRD42022326610). RESULTS: A total of 70 and 35 studies were included in the meta-analysis for OC and concordant CE (chorioretinitis with vitreous involvement), respectively. This study represented 8599 patients with candidemia who underwent ophthalmologic examination. Pooled prevalences (95% CI) of OC, overall CE, concordant CE, and discordant CE were 10.7% (8.4-13.5%), 3.1% (2.1-4.5%), 1.8% (1.3-2.6%), and 7.4% (4.5-12%) of patients screened, respectively. Studies from Asian countries had significantly higher concordant CE prevalence (95% CI) of patients screened (3.6%; 2.9-4.6%) compared with studies from European countries (1.4%; .4-5%) and American countries (1.4%; .9-2.2%) (P <.01). Presence of total parenteral nutrition and Candida albicans was associated with CE, with pooled odds ratios (95% CI) of 6.92 (3.58-13.36) and 3.02 (1.67-5.46), respectively. CONCLUSIONS: Prevalence of concordant CE overall and among Asian countries was 2 and 4 times higher than the prevalence previously reported by the American Academy of Ophthalmology (AAO) of <0.9%, respectively. There is an urgent need to study optimal screening protocols and to establish joint recommendations by the Infectious Diseases Society of America and AAO.