Gait and axial postural abnormalities correlations in Parkinson's disease: A multicenter quantitative study
Issued Date
2022-12-01
Resource Type
ISSN
13538020
eISSN
18735126
Scopus ID
2-s2.0-85140957734
Pubmed ID
36332288
Journal Title
Parkinsonism and Related Disorders
Volume
105
Start Page
19
End Page
23
Rights Holder(s)
SCOPUS
Bibliographic Citation
Parkinsonism and Related Disorders Vol.105 (2022) , 19-23
Suggested Citation
Pongmala C. Gait and axial postural abnormalities correlations in Parkinson's disease: A multicenter quantitative study. Parkinsonism and Related Disorders Vol.105 (2022) , 19-23. 23. doi:10.1016/j.parkreldis.2022.10.026 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85237
Title
Gait and axial postural abnormalities correlations in Parkinson's disease: A multicenter quantitative study
Author(s)
Author's Affiliation
Centre d'Investigation Clinique de Toulouse - CIC Toulouse
Siriraj Hospital
King Fahad Medical City
University of Michigan Medical School
Gyeongsang National University
Faculdade de Medicina, Universidade de Lisboa
Samsung Medical Center, Sungkyunkwan university
SKKU School of Medicine
Università degli Studi di Torino
Universitätsklinikum Schleswig-Holstein Campus Kiel
Instituto Medicina Molecular João Lobo Antunes
CNS—Campus Neurológico
Siriraj Hospital
King Fahad Medical City
University of Michigan Medical School
Gyeongsang National University
Faculdade de Medicina, Universidade de Lisboa
Samsung Medical Center, Sungkyunkwan university
SKKU School of Medicine
Università degli Studi di Torino
Universitätsklinikum Schleswig-Holstein Campus Kiel
Instituto Medicina Molecular João Lobo Antunes
CNS—Campus Neurológico
Other Contributor(s)
Abstract
Introduction: Gait and axial postural abnormalities (PA) are common and disabling symptoms of Parkinson's disease (PD). The interplay between them has been poorly explored. Methods: A standardized protocol encompassing videos and photos for posture and gait analysis of PD patients with a clinically defined PA (MDS-UPDRS-III item 3.13 > 0) was used in 6 movement disorder centers. A comprehensive evaluation was performed to clarify the association between gait performance and the presence and severity of PA. Results: 225 PD patients were enrolled: 57 had severe PA, 149 mild PA, and 19 did not meet criteria for PA, according to a recent consensus agreement on PA definition. PD patients with severe PA were significantly older (p:0.001), with longer disease duration (p:0.007), worse MDS-UPDRS-II and –III scores and axial sub-scores (p < 0.0005), higher LEDD (p:0.002) and HY stage (p < 0.0005), and a significantly lower velocity (p < 0.001) and cadence (p:0.021), if compared to mild PA patients. The multiple regression analysis evaluating gait parameters and degrees of trunk/neck flexion showed that higher degrees of lumbar anterior trunk flexion were correlated with lower step length (OR -0.244; p:0.014) and lower velocity (OR -0.005; p:0.028). Conclusions: Our results highlight the possible impact of severe anterior trunk flection on PD patients’ gait, with a specific detrimental effect on gait velocity and step length. Personalized rehabilitation strategies should be elaborated based on the different features of PA, aiming to target a combined treatment of postural and specifically related gait pattern alterations.