Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure
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Issued Date
2025-03-01
Resource Type
ISSN
27246507
eISSN
27246116
Scopus ID
2-s2.0-105000907802
Pubmed ID
37733292
Journal Title
Minerva Endocrinology
Volume
50
Issue
1
Start Page
50
End Page
60
Rights Holder(s)
SCOPUS
Bibliographic Citation
Minerva Endocrinology Vol.50 No.1 (2025) , 50-60
Suggested Citation
Sitticharoon C., Raksadawan Y., Boonpuan P., Keadkraichaiwat I., Sririwichitchai R., Maikaew P. Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure. Minerva Endocrinology Vol.50 No.1 (2025) , 50-60. 60. doi:10.23736/S2724-6507.22.03766-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/109333
Title
Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure
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Abstract
BACKGROUND: Kisspeptin has a major role in reproductive regulation. Furthermore, it is also involved in metabolic and cardiovascular regulation as well as is a potent vasoconstrictor. This study aimed to: 1) determine correlations between serum kisspeptin levels with obesity/metabolic parameters; 2) compare parameters between non-hypertensive ([non-HT] N.=15) and hypertensive ([HT] N.=15) female subjects; and 3) determine correlations between leptin, systolic blood pressure (SBP) or diastolic blood pressure (DBP) with obesity and metabolic factors. METHODS: Clinical parameters and fasting blood and adipose tissue samples were collected from women undergoing open abdominal surgery. RESULTS: Serum kisspeptin was not correlated with obesity parameters but was positively correlated with only SBP (P<0.05). Serum kisspeptin, SBP, DBP, body weight, waist circumference, hip circumference, plasma glucose, plasma insulin, the homeostatic model assessment for insulin resistance (HOMA-IR), and height of visceral adipocytes (VA) were higher but the Quantitative Insulin Sensitivity Check Index (QUICKI) was lower in hypertensive compared to non-hypertensive female subjects (P<0.05). Leptin was positively correlated with obesity and metabolic paramters including area, width, and perimeter of subcutaneous adipocytes, and area, width, height, and perimeter of VA (P<0.05) but was negatively correlated the QUICKI (P<0.001). SBP had positive correlations with insulin, glucose, HOMA-IR, and kisspeptin, but had a negative correlation with QUICKI (P<0.05). DBP had positive correlations with body weight, BMI, waist circumference, hip circumference, insulin, glucose, HOMA-IR, and width of VA (P<0.05), but had a negative correlation with the QUICKI (P<0.05). CONCLUSIONS: Kisspeptin, obesity especially visceral adiposity, and insulin resistance might contribute to increased blood pressure. Further studies are required to reveal the underlying mechanism of kisspeptin on metabolic and cardiovascular regulation.