The biventricular contribution to chronic pulmonary hypertension of the extremely premature infant
Issued Date
2023-02-01
Resource Type
ISSN
07438346
eISSN
14765543
Scopus ID
2-s2.0-85137041360
Pubmed ID
36008520
Journal Title
Journal of Perinatology
Volume
43
Issue
2
Start Page
174
End Page
180
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Perinatology Vol.43 No.2 (2023) , 174-180
Suggested Citation
de Carvalho Nunes G., Wutthigate P., Simoneau J., Dancea A., Beltempo M., Renaud C., Altit G. The biventricular contribution to chronic pulmonary hypertension of the extremely premature infant. Journal of Perinatology Vol.43 No.2 (2023) , 174-180. 180. doi:10.1038/s41372-022-01497-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82692
Title
The biventricular contribution to chronic pulmonary hypertension of the extremely premature infant
Author's Affiliation
Other Contributor(s)
Abstract
Objective: Evaluate factors associated with significant pulmonary hypertension [PH] (≥2/3 systemic) and its impact on ventricular function at 36 weeks postmenstrual age (PMA). Study design: Retrospective cohort of infants born at <29 weeks who survived to their echocardiography screening for PH at 36 weeks PMA. Masked experts extracted conventional and speckle-tracking echocardiography [STE] data. Results: Of 387 infants, 222 were included and 24 (11%) categorized as significant PH. Significant PH was associated with a decrease in tricuspid annular plane systolic excursion (0.79 vs 0.87 cm, p = 0.03), right peak longitudinal strain [pLS] by STE (−19.6 vs −23.1%, p = 0.003) and left pLS (−25.0 vs −22.7%, p = 0.02). The association between biventricular altered function by STE and significant PH persisted after adjustment for potential confounders – LV-pLS (p = 0.007) and RV-pLS (p = 0.01). Conclusion: Our findings are suggestive that premature newborns with significant PH at 36 weeks PMA have a biventricular cardiac involvement to their pathophysiology.