Evaluation of the In Vitro Antiparasitic Effect of the Essential Oil of Cymbopogon winterianus and Its Chemical Composition Analysis
Issued Date
2022-05-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85129008584
Pubmed ID
35566105
Journal Title
Molecules
Volume
27
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.27 No.9 (2022)
Suggested Citation
Pereira P.S., Oliveira C.V.B., Maia A.J., Vega-Gomez M.C., Rolón M., Coronel C., Duarte A.E., Coutinho H.D.M., Siyadatpanah A., Norouzi R., Sadati S.J.A., Wilairatana P., Silva T.G. Evaluation of the In Vitro Antiparasitic Effect of the Essential Oil of Cymbopogon winterianus and Its Chemical Composition Analysis. Molecules Vol.27 No.9 (2022). doi:10.3390/molecules27092753 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86863
Title
Evaluation of the In Vitro Antiparasitic Effect of the Essential Oil of Cymbopogon winterianus and Its Chemical Composition Analysis
Other Contributor(s)
Abstract
Cymbopogon winterianus, known as “citronella grass”, is an important aromatic and medicinal tropical herbaceous plant. The essential oil of C. winterianus (EOCw) is popularly used to play an important role in improving human health due to its potential as a bioactive component. The present study aimed to identify the components of the essential oil of C. winterianus and verify its leishmanicidal and trypanocidal potential, as well as the cytotoxicity in mammalian cells, in vitro. The EOCw had geraniol (42.13%), citronellal (17.31%), and citronellol (16.91%) as major constituents. The essential oil only exhibited significant cytotoxicity in mammalian fibroblasts at concentrations greater than 250 µg/mL, while regarding antipromastigote and antiepimastigote activities, they presented values considered clinically relevant, since both had LC50 < 62.5 µg/mL. It can be concluded that this is a pioneer study on the potential of the essential oil of C. winterianus and its use against the parasites T. cruzi and L. brasiliensis, and its importance is also based on this fact. Additionally, according to the results, C. winterianus was effective in presenting values of clinical relevance and low toxicity and, therefore, an indicator of popular use.